Facile stoichiometric reductions in flow: An example of artemisinin

Xiaolei Fan; Victor Sans; Polina Yaseneva; Dorota D. Plaza; Jonathan Williams; Alexei Lapkin

doi:10.1021/op200373m

Facile stoichiometric reductions in flow: An example of artemisinin

Xiaolei Fan, Victor Sans, Polina Yaseneva, Dorota D. Plaza, Jonathan Williams, Alexei Lapkin

Research output: Journal Publication › Article › peer-review

41 Citations (Scopus)

Abstract

Stoichiometric reduction of artemisinin to dihydroartemisinin (DHA) has been successfully transferred from batch to continuous flow conditions with a significant increase in productivity and an increase in selectivity. The DHA space-time-yield of up to 1.6 kg h ^-1 L ^-1 was attained which represents a 42 times increase in throughput compared to that of conventional batch process.

Original language	English
Pages (from-to)	1039-1042
Number of pages	4
Journal	Organic Process Research and Development
Volume	16
Issue number	5
DOIs	https://doi.org/10.1021/op200373m
Publication status	Published - 18 May 2012
Externally published	Yes

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/op200373m

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abstract = "Stoichiometric reduction of artemisinin to dihydroartemisinin (DHA) has been successfully transferred from batch to continuous flow conditions with a significant increase in productivity and an increase in selectivity. The DHA space-time-yield of up to 1.6 kg h -1 L -1 was attained which represents a 42 times increase in throughput compared to that of conventional batch process.",

author = "Xiaolei Fan and Victor Sans and Polina Yaseneva and Plaza, {Dorota D.} and Jonathan Williams and Alexei Lapkin",

year = "2012",

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doi = "10.1021/op200373m",

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AU - Fan, Xiaolei

AU - Sans, Victor

AU - Yaseneva, Polina

AU - Plaza, Dorota D.

AU - Williams, Jonathan

AU - Lapkin, Alexei

PY - 2012/5/18

Y1 - 2012/5/18

N2 - Stoichiometric reduction of artemisinin to dihydroartemisinin (DHA) has been successfully transferred from batch to continuous flow conditions with a significant increase in productivity and an increase in selectivity. The DHA space-time-yield of up to 1.6 kg h -1 L -1 was attained which represents a 42 times increase in throughput compared to that of conventional batch process.

AB - Stoichiometric reduction of artemisinin to dihydroartemisinin (DHA) has been successfully transferred from batch to continuous flow conditions with a significant increase in productivity and an increase in selectivity. The DHA space-time-yield of up to 1.6 kg h -1 L -1 was attained which represents a 42 times increase in throughput compared to that of conventional batch process.

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U2 - 10.1021/op200373m

DO - 10.1021/op200373m

M3 - Article

AN - SCOPUS:84862101865

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JO - Organic Process Research and Development

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ER -

Facile stoichiometric reductions in flow: An example of artemisinin

Abstract

ASJC Scopus subject areas

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