Effects of pulmonary inhalation on hyperpolarized krypton-83 magnetic resonance T1 relaxation

K. F. Stupic, N. D. Elkins, G. E. Pavlovskaya, J. E. Repine, T. Meersmann

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Abstract

The 83Kr magnetic resonance (MR) relaxation time T1 of krypton gas in contact with model surfaces was previously found to be highly sensitive to surface composition, surface-to-volume ratio, and surface temperature. The work presented here explored aspects of pulmonary 83Kr T1 relaxation measurements in excised lungs from healthy rats using hyperpolarized (hp) 83Kr with approximately 4.4% spin polarization. MR spectroscopy without spatial resolution was applied to the ex vivo lungs that actively inhale hp 83Kr through a custom designed ventilation system. Various inhalation schemes were devised to study the influence of anatomical dead space upon the measured 83Kr T 1 relaxation times. The longitudinal 83Kr relaxation times in the distal airways and the respiratory zones were independent of the lung inhalation volume, with T1 = 1.3 s and T1 = 1.0 s, depending only on the applied inhalation scheme. The obtained data were highly reproducible between different specimens. Further, the 83Kr T 1 relaxation times in excised lungs were unaffected by the presence of up to 40% oxygen in the hp gas mixture. The results support the possible importance of 83Kr as a biomarker for evaluating lung function.

Original languageEnglish
Pages (from-to)3731-3748
Number of pages18
JournalPhysics in Medicine and Biology
Volume56
Issue number13
DOIs
Publication statusPublished - 7 Jul 2011
Externally publishedYes

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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Stupic, K. F., Elkins, N. D., Pavlovskaya, G. E., Repine, J. E., & Meersmann, T. (2011). Effects of pulmonary inhalation on hyperpolarized krypton-83 magnetic resonance T1 relaxation. Physics in Medicine and Biology, 56(13), 3731-3748. https://doi.org/10.1088/0031-9155/56/13/001