TY - GEN
T1 - Development of C. albican Anti-attachment Inkjet 3D Printing Ink, via High Throughput Screening
AU - Yong, Ling Xin
AU - Zhou, Zuoxin
AU - Vallières, Cindy
AU - He, Yinfeng
AU - Crucitti, Valentina Cuzzucoli
AU - Alexander, Morgan R.
AU - Avery, Simon
AU - Wildman, Ricky
AU - Irvine, Derek
N1 - Publisher Copyright:
© The Author(s), under exclusive license to Springer Nature Switzerland AG 2025.
PY - 2025
Y1 - 2025
N2 - The fungal pathogen Candida albicans (C. albicans) is particularly problematic for immunocompromised patients and those with medical implants. Introducing Candida-resistant medical devices could potentially reduce mortality rates from such infections. Here, we develop the use of high throughput screening (HTS) methodology that can thoroughly and effectively screen a large number of methacrylate and acrylate monomers for their resistance to attachment by C. albicans. In this work, we demonstrate the method using nine selected methacrylate and acrylate monomers and specifically discuss the method developed for UV-curing based 3D printing (3DP) processes, focusing on inkjet printing. The HTS process considers the viscosity and surface tension of monomers for their printing performance, the resulting mechanical properties of its polymer, resistance to fungal attachment, and polymer toxicity towards C. albicans after inkjet printing. This HTS technique accelerates the evaluation and development of polymers with fungal anti-attachment properties for both medical and 3DP fields. Out of the nine polymers demonstrated, 4-tert-butylcyclohexyl acrylate (TBCHA), 4-tert-butylcyclohexyl methacrylate (TBCHMA) were both new fungal anti-attachment materials that were found to be printable using this methodology.
AB - The fungal pathogen Candida albicans (C. albicans) is particularly problematic for immunocompromised patients and those with medical implants. Introducing Candida-resistant medical devices could potentially reduce mortality rates from such infections. Here, we develop the use of high throughput screening (HTS) methodology that can thoroughly and effectively screen a large number of methacrylate and acrylate monomers for their resistance to attachment by C. albicans. In this work, we demonstrate the method using nine selected methacrylate and acrylate monomers and specifically discuss the method developed for UV-curing based 3D printing (3DP) processes, focusing on inkjet printing. The HTS process considers the viscosity and surface tension of monomers for their printing performance, the resulting mechanical properties of its polymer, resistance to fungal attachment, and polymer toxicity towards C. albicans after inkjet printing. This HTS technique accelerates the evaluation and development of polymers with fungal anti-attachment properties for both medical and 3DP fields. Out of the nine polymers demonstrated, 4-tert-butylcyclohexyl acrylate (TBCHA), 4-tert-butylcyclohexyl methacrylate (TBCHMA) were both new fungal anti-attachment materials that were found to be printable using this methodology.
KW - 3D printing
KW - Additive manufacturing
KW - Biomaterial
KW - Biomedical device
KW - Fungal anti-attachment
UR - http://www.scopus.com/inward/record.url?scp=85215593531&partnerID=8YFLogxK
U2 - 10.1007/978-3-031-81673-4_33
DO - 10.1007/978-3-031-81673-4_33
M3 - Conference contribution
AN - SCOPUS:85215593531
SN - 9783031816727
T3 - Mechanisms and Machine Science
SP - 437
EP - 452
BT - Computational and Experimental Simulations in Engineering - Proceedings of ICCES 2024 — International Conference on Computational and Experimental Engineering and Sciences ICCES
A2 - Zhou, Kun
PB - Springer Science and Business Media B.V.
T2 - 30th International Conference on Computational and Experimental Engineering and Sciences, ICCES 2024
Y2 - 3 August 2024 through 6 August 2024
ER -