@article{1a8159a6e1374b68a274daa34dd0c1aa,
title = "Chromosome 9p21.3 is associated with early-onset coronary heart disease in the Irish population",
abstract = "Coronary heart disease (CHD) remains a leading cause of death across the world. A region on chromosome 9p21.3 has been recently reported to be associated with CHD. We evaluated 3 SNPs and 3 common haplotypes in the 9p21.3 region in 1494 individuals from 580 Irish families, where at least 1 member had early-onset (males ≤55yr, females ≤60yr) CHD. Genotypes were determined by multiplex SNaPshot technology. Using the combined TDT/S-TDT test, the 3 single nucleotide polymorphisms (SNP), rs10757274, rs2383206 and rs1333049, were strongly associated with early-onset CHD (p = 2.7 × 10-6, 2.7 × 10-6, 3.8 × 10-7, respectively). Analysis of haplotypes by the TRANSMIT program also showed that the GGC haplotype was associated with early-onset CHD (p = 7.9 × 10-7). In conclusion, using a family-based approach in the Irish population, we have confirmed previous reports of association between a region on chromosome 9p21.3 and early-onset CHD.",
keywords = "Chromosome 9p21.3, Coronary heart disease, Genetics",
author = "Weihua Meng and Hughes, {Anne E.} and Patterson, {Chris C.} and Christine Belton and Frank Kee and McKeown, {Pascal P.}",
note = "Funding Information: Coronary heart disease (CHD) remains a leading cause of death across the world. A region on chromosome 9p21.3 has been recently reported to be associated with CHD. We evaluated 3 SNPs and 3 common haplotypes in the 9p21.3 region in 1494 individuals from 580 Irish families, where at least 1 member had early-onset (males ≤55yr, females ≤60yr) CHD. Genotypes were determined by multiplex SNaPshot technology. Using the combined TDT/S-TDT test, the 3 single nucleotide polymorphisms (SNP), rs10757274, rs2383206 and rs1333049, were strongly associated with early-onset CHD ( p = 2.7 × 10 -6 , 2.7 × 10 -6 , 3.8 × 10 -7 , respectively). Analysis of haplotypes by the TRANSMIT program also showed that the GGC haplotype was associated with early-onset CHD ( p = 7.9 × 10 -7 ). In conclusion, using a family-based approach in the Irish population, we have confirmed previous reports of association between a region on chromosome 9p21.3 and early-onset CHD. Coronary heart disease chromosome 9p21.3 genetics Northern Ireland Research and Development Office Royal Victoria Hospital Research Fellowship http://dx.doi.org/10.13039/501100000415 Northern Ireland Chest, Heart and Stroke Association Heart Trust Fund",
year = "2008",
doi = "10.1155/2008/375617",
language = "English",
volume = "25",
pages = "81--85",
journal = "Disease Markers",
issn = "0278-0240",
publisher = "Hindawi Limited",
number = "2",
}
