Biological insights into the piericidin family of microbial metabolites

Sepideh M. Azad; Yu Jin; Hooi Leng Ser; Bey Hing Goh; Learn Han Lee; Chitti Thawai; Ya Wen He

doi:10.1111/jam.15222

Biological insights into the piericidin family of microbial metabolites

Sepideh M. Azad, Yu Jin, Hooi Leng Ser, Bey Hing Goh, Learn Han Lee, Chitti Thawai, Ya Wen He

Research output: Journal Publication › Review article › peer-review

12 Citations (Scopus)

Abstract

Extensively produced by members of the genus Streptomyces, piericidins are a large family of microbial metabolites, which consist of main skeleton of 4-pyridinol with methylated polyketide side chain. Nonetheless, these metabolites show differences in their bioactive potentials against micro-organisms, insects and tumour cells. Due to its close structural similarity with coenzyme Q, piericidins also possess an inhibitory activity against NADH dehydrogenase as well as Photosystem II. This review studied the latest research progress of piericidins, covering the chemical structure and physical properties of newly identified members, bioactivities, biosynthetic pathway with gene clusters and future prospect. With the increasing incidence of drug-resistant human pathogen strains and cancers, this review aimed to provide clues for the development of either new potential antibiotics or anti-tumour agents.

Original language	English
Pages (from-to)	772-784
Number of pages	13
Journal	Journal of Applied Microbiology
Volume	132
Issue number	2
DOIs	https://doi.org/10.1111/jam.15222
Publication status	Published - Feb 2022
Externally published	Yes

ASJC Scopus subject areas

Biotechnology
Applied Microbiology and Biotechnology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/jam.15222

Cite this

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title = "Biological insights into the piericidin family of microbial metabolites",

abstract = "Extensively produced by members of the genus Streptomyces, piericidins are a large family of microbial metabolites, which consist of main skeleton of 4-pyridinol with methylated polyketide side chain. Nonetheless, these metabolites show differences in their bioactive potentials against micro-organisms, insects and tumour cells. Due to its close structural similarity with coenzyme Q, piericidins also possess an inhibitory activity against NADH dehydrogenase as well as Photosystem II. This review studied the latest research progress of piericidins, covering the chemical structure and physical properties of newly identified members, bioactivities, biosynthetic pathway with gene clusters and future prospect. With the increasing incidence of drug-resistant human pathogen strains and cancers, this review aimed to provide clues for the development of either new potential antibiotics or anti-tumour agents.",

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AU - Azad, Sepideh M.

AU - Jin, Yu

AU - Ser, Hooi Leng

AU - Goh, Bey Hing

AU - Lee, Learn Han

AU - Thawai, Chitti

AU - He, Ya Wen

PY - 2022/2

Y1 - 2022/2

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AB - Extensively produced by members of the genus Streptomyces, piericidins are a large family of microbial metabolites, which consist of main skeleton of 4-pyridinol with methylated polyketide side chain. Nonetheless, these metabolites show differences in their bioactive potentials against micro-organisms, insects and tumour cells. Due to its close structural similarity with coenzyme Q, piericidins also possess an inhibitory activity against NADH dehydrogenase as well as Photosystem II. This review studied the latest research progress of piericidins, covering the chemical structure and physical properties of newly identified members, bioactivities, biosynthetic pathway with gene clusters and future prospect. With the increasing incidence of drug-resistant human pathogen strains and cancers, this review aimed to provide clues for the development of either new potential antibiotics or anti-tumour agents.

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Biological insights into the piericidin family of microbial metabolites

Abstract

ASJC Scopus subject areas

UN SDGs

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