Basal expression of bradykinin B1 receptor in peripheral sensory ganglia in the rat

Qing Ping Ma; Ray Hill; Dalip Sirinathsinghji

doi:10.1097/00001756-200012180-00020

Basal expression of bradykinin B₁ receptor in peripheral sensory ganglia in the rat

Qing Ping Ma, Ray Hill, Dalip Sirinathsinghji

Research output: Journal Publication › Article › peer-review

48 Citations (Scopus)

Abstract

The bradykinin B₁ receptor is thought to be induced by tissue injurY and inflammation. In the present study, we have investigated whether there is a basal expression of B₁ receptor in dorsal root ganglion (DRG) and trigeminal ganglion neurons in rats. A substantial number of neurons in both DRGs and trigeminal ganglia were found to be B₁-immunoreactive in rats. Both small and medium-sized DRG neurons were B₁-immunoreactive, suggesting that they are likely to be Aδ- or C-fibre neurons which are involved in nociceptive transmission. These results support a possible role for B₁ receptors in the modulation of nociceptive sensorY transmission.

Original language	English
Pages (from-to)	4003-4005
Number of pages	3
Journal	NeuroReport
Volume	11
Issue number	18
DOIs	https://doi.org/10.1097/00001756-200012180-00020
Publication status	Published - 2000
Externally published	Yes

Keywords

B receptor
B receptor knock-out
Bradykinin
Dorsal root ganglia (DRG)
Immunohistochemistry
Trigeminal nerve ganglia

ASJC Scopus subject areas

General Neuroscience

Access to Document

10.1097/00001756-200012180-00020

Cite this

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title = "Basal expression of bradykinin B1 receptor in peripheral sensory ganglia in the rat",

abstract = "The bradykinin B1 receptor is thought to be induced by tissue injurY and inflammation. In the present study, we have investigated whether there is a basal expression of B1 receptor in dorsal root ganglion (DRG) and trigeminal ganglion neurons in rats. A substantial number of neurons in both DRGs and trigeminal ganglia were found to be B1-immunoreactive in rats. Both small and medium-sized DRG neurons were B1-immunoreactive, suggesting that they are likely to be Aδ- or C-fibre neurons which are involved in nociceptive transmission. These results support a possible role for B1 receptors in the modulation of nociceptive sensorY transmission.",

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T1 - Basal expression of bradykinin B1 receptor in peripheral sensory ganglia in the rat

AU - Ma, Qing Ping

AU - Hill, Ray

AU - Sirinathsinghji, Dalip

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N2 - The bradykinin B1 receptor is thought to be induced by tissue injurY and inflammation. In the present study, we have investigated whether there is a basal expression of B1 receptor in dorsal root ganglion (DRG) and trigeminal ganglion neurons in rats. A substantial number of neurons in both DRGs and trigeminal ganglia were found to be B1-immunoreactive in rats. Both small and medium-sized DRG neurons were B1-immunoreactive, suggesting that they are likely to be Aδ- or C-fibre neurons which are involved in nociceptive transmission. These results support a possible role for B1 receptors in the modulation of nociceptive sensorY transmission.

AB - The bradykinin B1 receptor is thought to be induced by tissue injurY and inflammation. In the present study, we have investigated whether there is a basal expression of B1 receptor in dorsal root ganglion (DRG) and trigeminal ganglion neurons in rats. A substantial number of neurons in both DRGs and trigeminal ganglia were found to be B1-immunoreactive in rats. Both small and medium-sized DRG neurons were B1-immunoreactive, suggesting that they are likely to be Aδ- or C-fibre neurons which are involved in nociceptive transmission. These results support a possible role for B1 receptors in the modulation of nociceptive sensorY transmission.

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KW - B receptor knock-out

KW - Bradykinin

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KW - Immunohistochemistry

KW - Trigeminal nerve ganglia

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