Association of CCR5 Δ32 with reduced risk of asthma

Ian P. Hall; Amanda Wheatley; Gordon Christie; Catherine McDougall; Richard Hubbard; Peter J. Helms

doi:10.1016/S0140-6736(99)03425-X

Association of CCR5 Δ32 with reduced risk of asthma

Ian P. Hall, Amanda Wheatley, Gordon Christie, Catherine McDougall, Richard Hubbard, Peter J. Helms

Research output: Journal Publication › Article › peer-review

105 Citations (Scopus)

Abstract

We report that individuals carrying the CCR5Δ32 mutation, a naturally occurring variant of the C-C chemokine receptor 5 (CCR5), are at reduced risk of developing asthma. These data suggest a possible explanation for the high prevalence of this mutation in the general population.

Original language	English
Pages (from-to)	1264-1265
Number of pages	2
Journal	The Lancet
Volume	354
Issue number	9186
DOIs	https://doi.org/10.1016/S0140-6736(99)03425-X
Publication status	Published - 9 Oct 1999
Externally published	Yes

ASJC Scopus subject areas

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0140-6736(99)03425-X

Cite this

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title = "Association of CCR5 Δ32 with reduced risk of asthma",

abstract = "We report that individuals carrying the CCR5Δ32 mutation, a naturally occurring variant of the C-C chemokine receptor 5 (CCR5), are at reduced risk of developing asthma. These data suggest a possible explanation for the high prevalence of this mutation in the general population.",

author = "Hall, {Ian P.} and Amanda Wheatley and Gordon Christie and Catherine McDougall and Richard Hubbard and Helms, {Peter J.}",

year = "1999",

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T1 - Association of CCR5 Δ32 with reduced risk of asthma

AU - Hall, Ian P.

AU - Wheatley, Amanda

AU - Christie, Gordon

AU - McDougall, Catherine

AU - Hubbard, Richard

AU - Helms, Peter J.

PY - 1999/10/9

Y1 - 1999/10/9

N2 - We report that individuals carrying the CCR5Δ32 mutation, a naturally occurring variant of the C-C chemokine receptor 5 (CCR5), are at reduced risk of developing asthma. These data suggest a possible explanation for the high prevalence of this mutation in the general population.

AB - We report that individuals carrying the CCR5Δ32 mutation, a naturally occurring variant of the C-C chemokine receptor 5 (CCR5), are at reduced risk of developing asthma. These data suggest a possible explanation for the high prevalence of this mutation in the general population.

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U2 - 10.1016/S0140-6736(99)03425-X

DO - 10.1016/S0140-6736(99)03425-X

M3 - Article

C2 - 10520641

AN - SCOPUS:0033539191

SN - 0140-6736

VL - 354

SP - 1264

EP - 1265

JO - The Lancet

JF - The Lancet

IS - 9186

ER -

Association of CCR5 Δ32 with reduced risk of asthma

Abstract

ASJC Scopus subject areas

UN SDGs

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