Application of supercritical antisolvent technology in the preparation of paracetamol-PEG4000 solid dispersions

Supercritical antisolvent processes for the preparations of pharmaceutical solid dispersions of paracetamol and PEG4000 have been studied. The correlations of the operation parameters on the processes were discussed. The physical characterization of the binary dispersions was determined using scanning electron microscopy, X-ray diffraction and differential scanning calorimetry. It was found that the dispersion and surface area of paracetamol in carrier PEG4000 were increased after PCA (precipitation with a compressed fluid antisolvent) and GAS (gas antisolvent sprany) process, and the dissolution were increased either. The studies proved that supercritical fluid antisolvent technology was an alternative method of preparing solid dispersion.