Zinc-based metal–organic frameworks for encapsulation and sustained release of ciprofloxacin for excellent antibacterial activities

Abdul Rauf, Mohsin Javed, Muhammad Jahangir, Mehdi Hassan, Anam Tariq, Wajahat Ali, Ali Bahadur, Shahid Iqbal, Sajid Mahmood, Khalid M. Alotaibi, Matar Alshalwi

Research output: Journal PublicationArticlepeer-review

1 Citation (Scopus)

Abstract

BACKGROUND: In terms of crystalline nanoporous materials, metal–organic frameworks (MOFs) are relatively new. They are self-assembling structures made of organic ligands that serve as linkers between metal centers and metal ions that function as coordination centers. Due to MOFs' high porosity, absence of nonaccessible bulk volume, vast surface areas and variety of pore sizes and topologies, drug delivery via them is becoming more and more common. RESULTS: Zn-MOF and Zn-MOF@drug were produced using a solvothermal approach in this study and characterized using a variety of methods, including Fourier transform infrared spectroscopy, powder X-ray diffraction and scanning electron microscopy. Utilizing the zone of inhibition and minimum inhibitory concentration approaches, Zn-MOF and Zn-MOF@drug were evaluated for their antibacterial capability against Escherichia coli and Bacillus subtilis, two types of bacteria. CONCLUSION: The antibacterial potential of Zn-MOF@drug was greater than that of the metal salt, commercially available ZnO, Zn-MOF and ligand alone. The mechanism of antibacterial activity of Zn-MOF@drug was also discussed.

Original languageEnglish
Pages (from-to)2545-2552
Number of pages8
JournalJournal of Chemical Technology and Biotechnology
Volume99
Issue number12
DOIs
Publication statusPublished - Dec 2024

Keywords

  • Zn-MOF
  • antibacterial activity
  • antibacterial mechanism
  • drug delivery
  • solvothermal

ASJC Scopus subject areas

  • Biotechnology
  • General Chemical Engineering
  • Renewable Energy, Sustainability and the Environment
  • Fuel Technology
  • Waste Management and Disposal
  • Pollution
  • Organic Chemistry
  • Inorganic Chemistry

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