Water-soluble chlorin e6-hydroxypropyl chitosan as a high-efficiency photoantimicrobial agent against Staphylococcus aureus

Lin Yue, Meihong Zheng, Min Wang, Imran Mahmood Khan, Xiaowei Ding, Yin Zhang, Zhouping Wang

Research output: Journal PublicationArticlepeer-review

6 Citations (Scopus)

Abstract

The development of new antimicrobial agents is important to combat infections caused by pathogenic bacteria. Herein, Hydroxypropyl chitosan (HPCS), a hydrophilic modified product of chitosan (CS), was employed as a carrier of the photosensitizer chlorin e6 (Ce6) through an amide bond to obtain the products (HPCS-Ce6 conjugates) with a degree of substitution (DS) ranging from 2.95% to 5.25%. The UV–vis absorption spectra and 1H NMR spectra confirmed the successful synthesis of the products. The products have a better and more stable reactive oxygen species (ROS) generation capacity and higher bacterial affinity than Ce6. At a very low dose (1.8 μg/mL), the highest DS product (HPCS-Ce6-3) can effectively kill Staphylococcus aureus (S. aureus) under 660 nm irradiation. In addition, the HPCS-Ce6 conjugates showed high biocompatibility in the CCK-8 test. The HPCS-Ce6 conjugates could be a photodynamic antibacterial agent with good water solubility, high biocompatibility, and antibacterial activity.

Original languageEnglish
Pages (from-to)669-677
Number of pages9
JournalInternational Journal of Biological Macromolecules
Volume208
DOIs
Publication statusPublished - 31 May 2022
Externally publishedYes

Keywords

  • Antibacterial properties
  • Chitosan
  • Chlorin e6
  • Hydroxypropylation
  • Photodynamic

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry
  • Molecular Biology

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