Variants in the nestin gene and coronary heart disease

Weihua Meng, Chris C. Patterson, Christine Belton, Anne Hughes, Pascal P. McKeown

Research output: Journal PublicationArticlepeer-review

4 Citations (Scopus)

Abstract

Background: The intermediate filament protein, nestin, may play a role in tissue regeneration and nestin expression has been detected in coronary atherosclerotic plaques. To date, no population-based studies concerning the role of the nestin gene in coronary heart disease (CHD) have been reported. Methods and Results: The 3 SNPs in the nestin gene were genotyped in 1,494 individuals from 580 Irish families. rs11582300 and rs3748570 were associated with early-onset CHD (p=0.04 and p=0.02). Conclusion: Nestin gene variants are associated with early-onset CHD. Further research on nestin's role in atherosclerosis is required.

Original languageEnglish
Pages (from-to)1538-1539
Number of pages2
JournalCirculation Journal
Volume72
Issue number9
DOIs
Publication statusPublished - 2008
Externally publishedYes

Keywords

  • Coronary heart disease
  • Nestin
  • Polymorphism

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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