TY - JOUR
T1 - UV PhotoVap
T2 - Demonstrating How a Simple and Versatile Reactor Based on a Conventional Rotary Evaporator Can Be Used for UV Photochemistry
AU - Clark, Charlotte A.
AU - Lee, Darren S.
AU - Pickering, Stephen J.
AU - Poliakoff, Martyn
AU - George, Michael W.
N1 - Publisher Copyright:
© 2018 American Chemical Society.
PY - 2018/5/18
Y1 - 2018/5/18
N2 - We report the use of a simple rotary evaporator as a semi-continuous UV photochemical reactor. By generation of a thin film from the rotation of a flask, better light penetration is achieved, and in this work we used high-power Hg lamps to enable the direct irradiation of molecules with UV light. The intramolecular [2 + 2] photocycloaddition of Cookson's dione and the intermolecular [2 + 2] photocycloaddition of maleimide with 1-hexyne were used as test reactions to examine the effectiveness of this reactor. High productivities, equivalent to 210 g h-1, were obtained for the simple intramolecular reaction, demonstrating the scalability of the reactor. The effects of flask size, reaction mixture volume, and use of borosilicate or quartz glassware were also investigated.
AB - We report the use of a simple rotary evaporator as a semi-continuous UV photochemical reactor. By generation of a thin film from the rotation of a flask, better light penetration is achieved, and in this work we used high-power Hg lamps to enable the direct irradiation of molecules with UV light. The intramolecular [2 + 2] photocycloaddition of Cookson's dione and the intermolecular [2 + 2] photocycloaddition of maleimide with 1-hexyne were used as test reactions to examine the effectiveness of this reactor. High productivities, equivalent to 210 g h-1, were obtained for the simple intramolecular reaction, demonstrating the scalability of the reactor. The effects of flask size, reaction mixture volume, and use of borosilicate or quartz glassware were also investigated.
UR - http://www.scopus.com/inward/record.url?scp=85051351060&partnerID=8YFLogxK
U2 - 10.1021/acs.oprd.8b00037
DO - 10.1021/acs.oprd.8b00037
M3 - Article
AN - SCOPUS:85051351060
SN - 1083-6160
VL - 22
SP - 595
EP - 599
JO - Organic Process Research and Development
JF - Organic Process Research and Development
IS - 5
ER -