Untargeted metabolomics study of mature human milk from women with and without gestational diabetes mellitus

Dan Yao; Cai Shen; Xinghe Zhang; Jiayue Tang; Jingwen Yu; Maolin Tu; Worawan Panpipat; Manat Chaijan; Hong Zhang; Xuebing Xu; Yanan Liu; Ling Zhi Cheong

doi:10.1016/j.foodchem.2024.140663

Untargeted metabolomics study of mature human milk from women with and without gestational diabetes mellitus

Dan Yao, Cai Shen, Xinghe Zhang, Jiayue Tang, Jingwen Yu, Maolin Tu, Worawan Panpipat, Manat Chaijan, Hong Zhang, Xuebing Xu, Yanan Liu, Ling Zhi Cheong

Research output: Journal Publication › Article › peer-review

Abstract

Gestational diabetes mellitus (GDM) is a prevalent metabolic disorder during pregnancy that alters the metabolites in human milk. Integrated Gas Chromatography-Mass Spectrometry (GC–MS) and Liquid Chromatography-Mass Spectrometry (LC-MS) were employed for comprehensive identification and comparison of metabolites in mature human milk (MHM) from women with and without GDM. A total of 268 differentially expressed metabolites (DEMs) were identified. Among these, linoleic acid, arachidonic acid, 9R-HODE and L-glutamic acid were significantly elevated and 12,13-DHOME was significantly decreased in MHM of women with GDM. These metabolites are significantly enriched in linoleic acid metabolism, fatty acid biosynthesis, galactose metabolism and ABC transporters pathways. Disorders in these metabolic pathways are associated with insulin resistance and poor glucose metabolism indicating these conditions may persist postpartum.

Original language	English
Article number	140663
Journal	Food Chemistry
Volume	460
DOIs	https://doi.org/10.1016/j.foodchem.2024.140663
Publication status	Published - 1 Dec 2024
Externally published	Yes

Keywords

Bioinformatic analysis
Gestational diabetes mellitus
Linoleic acid metabolism disorder
Mass spectrometry-based metabolomics
Mature human Milk

ASJC Scopus subject areas

Analytical Chemistry
Food Science

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.foodchem.2024.140663

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title = "Untargeted metabolomics study of mature human milk from women with and without gestational diabetes mellitus",

abstract = "Gestational diabetes mellitus (GDM) is a prevalent metabolic disorder during pregnancy that alters the metabolites in human milk. Integrated Gas Chromatography-Mass Spectrometry (GC–MS) and Liquid Chromatography-Mass Spectrometry (LC-MS) were employed for comprehensive identification and comparison of metabolites in mature human milk (MHM) from women with and without GDM. A total of 268 differentially expressed metabolites (DEMs) were identified. Among these, linoleic acid, arachidonic acid, 9R-HODE and L-glutamic acid were significantly elevated and 12,13-DHOME was significantly decreased in MHM of women with GDM. These metabolites are significantly enriched in linoleic acid metabolism, fatty acid biosynthesis, galactose metabolism and ABC transporters pathways. Disorders in these metabolic pathways are associated with insulin resistance and poor glucose metabolism indicating these conditions may persist postpartum.",

keywords = "Bioinformatic analysis, Gestational diabetes mellitus, Linoleic acid metabolism disorder, Mass spectrometry-based metabolomics, Mature human Milk",

author = "Dan Yao and Cai Shen and Xinghe Zhang and Jiayue Tang and Jingwen Yu and Maolin Tu and Worawan Panpipat and Manat Chaijan and Hong Zhang and Xuebing Xu and Yanan Liu and Cheong, {Ling Zhi}",

note = "Publisher Copyright: {\textcopyright} 2024 The Authors",

year = "2024",

month = dec,

day = "1",

doi = "10.1016/j.foodchem.2024.140663",

language = "English",

volume = "460",

journal = "Food Chemistry",

issn = "0308-8146",

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T1 - Untargeted metabolomics study of mature human milk from women with and without gestational diabetes mellitus

AU - Yao, Dan

AU - Shen, Cai

AU - Zhang, Xinghe

AU - Tang, Jiayue

AU - Yu, Jingwen

AU - Tu, Maolin

AU - Panpipat, Worawan

AU - Chaijan, Manat

AU - Zhang, Hong

AU - Xu, Xuebing

AU - Liu, Yanan

AU - Cheong, Ling Zhi

PY - 2024/12/1

Y1 - 2024/12/1

N2 - Gestational diabetes mellitus (GDM) is a prevalent metabolic disorder during pregnancy that alters the metabolites in human milk. Integrated Gas Chromatography-Mass Spectrometry (GC–MS) and Liquid Chromatography-Mass Spectrometry (LC-MS) were employed for comprehensive identification and comparison of metabolites in mature human milk (MHM) from women with and without GDM. A total of 268 differentially expressed metabolites (DEMs) were identified. Among these, linoleic acid, arachidonic acid, 9R-HODE and L-glutamic acid were significantly elevated and 12,13-DHOME was significantly decreased in MHM of women with GDM. These metabolites are significantly enriched in linoleic acid metabolism, fatty acid biosynthesis, galactose metabolism and ABC transporters pathways. Disorders in these metabolic pathways are associated with insulin resistance and poor glucose metabolism indicating these conditions may persist postpartum.

AB - Gestational diabetes mellitus (GDM) is a prevalent metabolic disorder during pregnancy that alters the metabolites in human milk. Integrated Gas Chromatography-Mass Spectrometry (GC–MS) and Liquid Chromatography-Mass Spectrometry (LC-MS) were employed for comprehensive identification and comparison of metabolites in mature human milk (MHM) from women with and without GDM. A total of 268 differentially expressed metabolites (DEMs) were identified. Among these, linoleic acid, arachidonic acid, 9R-HODE and L-glutamic acid were significantly elevated and 12,13-DHOME was significantly decreased in MHM of women with GDM. These metabolites are significantly enriched in linoleic acid metabolism, fatty acid biosynthesis, galactose metabolism and ABC transporters pathways. Disorders in these metabolic pathways are associated with insulin resistance and poor glucose metabolism indicating these conditions may persist postpartum.

KW - Bioinformatic analysis

KW - Gestational diabetes mellitus

KW - Linoleic acid metabolism disorder

KW - Mass spectrometry-based metabolomics

KW - Mature human Milk

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U2 - 10.1016/j.foodchem.2024.140663

DO - 10.1016/j.foodchem.2024.140663

M3 - Article

C2 - 39142199

AN - SCOPUS:85201015797

SN - 0308-8146

VL - 460

JO - Food Chemistry

JF - Food Chemistry

M1 - 140663

ER -

Untargeted metabolomics study of mature human milk from women with and without gestational diabetes mellitus

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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