Two-dimensional Nitrogenated Holey Graphene (C2N) monolayer based glucose sensor for diabetes mellitus

Puspamitra Panigrahi, Muhammad Sajjad, Deobrat Singh, Tanveer Hussain, J. Andreas Larsson, Rajeev Ahuja, Nirpendra Singh

Research output: Journal PublicationArticlepeer-review

17 Citations (Scopus)


Real-time monitoring of sugar molecules is crucial for diagnosis, controlling, and preventing diabetes. Here, we have proposed the potential of porous C2N monolayer-based glucose sensor to detect the sugar molecules (glucose, fructose, and xylose) by employing the van der Waals interactions corrected first-principles density functional theory and non-equilibrium Green's function methods. The binding energy turns out to be −0.93 (−1.31) eV for glucose, −0.84 (−1.23) eV for fructose, and −0.81 (−1.30) eV for xylose in gas phase (aqueous medium). The Bader charge analysis reveals that the C2N monolayer donates charge to the sugar molecules. The dimensionless electron localization function highlights that glucose, fructose, and xylose bind through physisorption. The adsorption of sugar molecules on the C2N monolayer increases the workfunction compared to 3.54 eV (pristine C2N) with about 2.00 eV, indicating a suppressed probability of electron mobility. The electronic transport properties of C2N based device reveals distinct characteristics and zero-bias transmissions. The distinctive properties of the C2N monolayer can be indexed as promising identifiers for glucose sensors to detect blood sugar.

Original languageEnglish
Article number151579
JournalApplied Surface Science
Publication statusPublished - 30 Jan 2022
Externally publishedYes


  • 2D Materials
  • Electron Localization Function (ELF)
  • First-principles Calculations
  • Glucose Sensor
  • Nitrogenated Holey Graphene
  • Non-equilibrium Green's function (NEGF)

ASJC Scopus subject areas

  • Chemistry (all)
  • Condensed Matter Physics
  • Physics and Astronomy (all)
  • Surfaces and Interfaces
  • Surfaces, Coatings and Films


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