The Emerging Role of MMP12 in the Oral Environment

Bingpeng Lin, Hooi Leng Ser, Lijing Wang, Jiang Li, Kok Gan Chan, Learn Han Lee, Loh Teng Hern Tan

Research output: Journal PublicationReview articlepeer-review

3 Citations (Scopus)


Matrix metalloproteinase-12 (MMP12), or macrophage metalloelastase, plays important roles in extracellular matrix (ECM) component degradation. Recent reports show MMP12 has been implicated in the pathogenesis of periodontal diseases. To date, this review represents the latest comprehensive overview of MMP12 in various oral diseases, such as periodontitis, temporomandibular joint dysfunction (TMD), orthodontic tooth movement (OTM), and oral squamous cell carcinoma (OSCC). Furthermore, the current knowledge regarding the distribution of MMP12 in different tissues is also illustrated in this review. Studies have implicated the association of MMP12 expression with the pathogenesis of several representative oral diseases, including periodontitis, TMD, OSCC, OTM, and bone remodelling. Although there may be a potential role of MMP12 in oral diseases, the exact pathophysiological role of MMP12 remains to be elucidated. Understanding the cellular and molecular biology of MMP12 is essential, as MMP12 could be a potential target for developing therapeutic strategies targeting inflammatory and immunologically related oral diseases.

Original languageEnglish
Article number4648
JournalInternational Journal of Molecular Sciences
Issue number5
Publication statusPublished - Mar 2023
Externally publishedYes


  • MMP12
  • OSCC
  • OTM
  • bone remodelling
  • periodontitis
  • tissue expression

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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