Synthesis of antimalarial trioxanes via continuous photo-oxidation with 1O2 in supercritical CO2

Jessica F.B. Hall; Richard A. Bourne; Xue Han; James H. Earley; Martyn Poliakoff; Michael W. George

doi:10.1039/c2gc36711d

Synthesis of antimalarial trioxanes via continuous photo-oxidation with ¹O₂ in supercritical CO₂

Jessica F.B. Hall, Richard A. Bourne, Xue Han, James H. Earley, Martyn Poliakoff, Michael W. George

Research output: Journal Publication › Article › peer-review

35 Citations (Scopus)

Abstract

The oxidation of an allylic alcohol to its hydroperoxides represents a key step in the synthesis of a series of spirobicyclic, antimalarial trioxanes. Herein, we investigate the continuous photo-oxidation of an allylic alcohol with ¹O₂ in scCO₂, as a 'green' alternative to conventional methods, and examine the remaining two steps in the synthesis of antimalarial trioxanes from readily available starting materials.

Original language	English
Pages (from-to)	177-180
Number of pages	4
Journal	Green Chemistry
Volume	15
Issue number	1
DOIs	https://doi.org/10.1039/c2gc36711d
Publication status	Published - Jan 2013
Externally published	Yes

ASJC Scopus subject areas

Environmental Chemistry
Pollution

Access to Document

10.1039/c2gc36711d

Cite this

@article{17aa67fb0c154dcbb7bb2e00409f8846,

title = "Synthesis of antimalarial trioxanes via continuous photo-oxidation with 1O2 in supercritical CO2",

abstract = "The oxidation of an allylic alcohol to its hydroperoxides represents a key step in the synthesis of a series of spirobicyclic, antimalarial trioxanes. Herein, we investigate the continuous photo-oxidation of an allylic alcohol with 1O2 in scCO2, as a 'green' alternative to conventional methods, and examine the remaining two steps in the synthesis of antimalarial trioxanes from readily available starting materials.",

author = "Hall, {Jessica F.B.} and Bourne, {Richard A.} and Xue Han and Earley, {James H.} and Martyn Poliakoff and George, {Michael W.}",

year = "2013",

month = jan,

doi = "10.1039/c2gc36711d",

language = "English",

volume = "15",

pages = "177--180",

journal = "Green Chemistry",

issn = "1463-9262",

publisher = "Royal Society of Chemistry",

number = "1",

}

TY - JOUR

T1 - Synthesis of antimalarial trioxanes via continuous photo-oxidation with 1O2 in supercritical CO2

AU - Hall, Jessica F.B.

AU - Bourne, Richard A.

AU - Han, Xue

AU - Earley, James H.

AU - Poliakoff, Martyn

AU - George, Michael W.

PY - 2013/1

Y1 - 2013/1

N2 - The oxidation of an allylic alcohol to its hydroperoxides represents a key step in the synthesis of a series of spirobicyclic, antimalarial trioxanes. Herein, we investigate the continuous photo-oxidation of an allylic alcohol with 1O2 in scCO2, as a 'green' alternative to conventional methods, and examine the remaining two steps in the synthesis of antimalarial trioxanes from readily available starting materials.

AB - The oxidation of an allylic alcohol to its hydroperoxides represents a key step in the synthesis of a series of spirobicyclic, antimalarial trioxanes. Herein, we investigate the continuous photo-oxidation of an allylic alcohol with 1O2 in scCO2, as a 'green' alternative to conventional methods, and examine the remaining two steps in the synthesis of antimalarial trioxanes from readily available starting materials.

UR - http://www.scopus.com/inward/record.url?scp=84871748614&partnerID=8YFLogxK

U2 - 10.1039/c2gc36711d

DO - 10.1039/c2gc36711d

M3 - Article

AN - SCOPUS:84871748614

SN - 1463-9262

VL - 15

SP - 177

EP - 180

JO - Green Chemistry

JF - Green Chemistry

IS - 1

ER -

Synthesis of antimalarial trioxanes via continuous photo-oxidation with ¹O₂ in supercritical CO₂

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this