Synthesis of antimalarial trioxanes via continuous photo-oxidation with 1O2 in supercritical CO2

Jessica F.B. Hall, Richard A. Bourne, Xue Han, James H. Earley, Martyn Poliakoff, Michael W. George

Research output: Journal PublicationArticlepeer-review

34 Citations (Scopus)

Abstract

The oxidation of an allylic alcohol to its hydroperoxides represents a key step in the synthesis of a series of spirobicyclic, antimalarial trioxanes. Herein, we investigate the continuous photo-oxidation of an allylic alcohol with 1O2 in scCO2, as a 'green' alternative to conventional methods, and examine the remaining two steps in the synthesis of antimalarial trioxanes from readily available starting materials.

Original languageEnglish
Pages (from-to)177-180
Number of pages4
JournalGreen Chemistry
Volume15
Issue number1
DOIs
Publication statusPublished - Jan 2013
Externally publishedYes

ASJC Scopus subject areas

  • Environmental Chemistry
  • Pollution

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