Synthesis and antibacterial properties of new monomethyl fumaric acid-modified chitosan oligosaccharide derivatives

Lingyu Zhao, Imran Mahmood Khan, Bin Wang, Lin Yue, Yin Zhang, Zhouping Wang, Wenshui Xia

Research output: Journal PublicationArticlepeer-review

4 Citations (Scopus)

Abstract

Inventions into chitosan oligosaccharide (COS) derivatives over recent decades have hugely broadened their application in food safety. Herein, monomethyl fumaric acid (MFA) was grafted on the OH position of COS to synthesise new COS-O-MFA derivatives and evaluated their in vitro antibacterial properties. The degrees of substitution (DS) of the derivatives yielded almost 15% with the range of 0.093 to 0.260. The in vitro antibacterial properties of the new COS-O-MFA1-3 derivatives against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) were significantly enhanced concerning COS. Based on the finding, the introduction of MFA and increasing DS have a great impact on the enhancement of antibacterial properties of the COS-O-MFA1-3 derivatives. This work proves that COS-O-MFA1-3 derivatives can be potential novel antibacterial agents and also open up a new avenue to improve their antibacterial attributes.

Original languageEnglish
Pages (from-to)2872-2878
Number of pages7
JournalInternational Journal of Food Science and Technology
Volume57
Issue number5
DOIs
Publication statusPublished - May 2022
Externally publishedYes

Keywords

  • Antimicrobial activity
  • chemical modification
  • chitosan oligosaccharide

ASJC Scopus subject areas

  • Food Science
  • Industrial and Manufacturing Engineering

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