Structure and properties of nano-hydroxypatite scaffolds for bone tissue engineering with a selective laser sintering system

Cijun Shuai, Chengde Gao, Yi Nie, Huanlong Hu, Ying Zhou, Shuping Peng

Research output: Journal PublicationArticlepeer-review

99 Citations (Scopus)

Abstract

In this study, nano-hydroxypatite (n-HAP) bone scaffolds are prepared by a homemade selective laser sintering (SLS) system based on rapid prototyping (RP) technology. The SLS system consists of a precise three-axis motion platform and a laser with its optical focusing device. The implementation of arbitrary complex movements based on the non-uniform rational B-Spline (NURBS) theory is realized in this system. The effects of the sintering processing parameters on the microstructure of n-HAP are tested with x-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy and scanning electron microscopy (SEM). The particles of n-HAP grow gradually and tend to become spherical-like from the initial needle-like shape, but still maintain a nanoscale structure at scanning speeds between 200 and 300mmmin- 1 when the laser power is 50W, the light spot diameter 4mm, and the layer thickness 0.3mm. In addition, these changes do not result in decomposition of the n-HAP during the sintering process. The results suggest that the newly developed n-HAP scaffolds have the potential to serve as an excellent substrate in bone tissue engineering.

Original languageEnglish
Article number285703
JournalNanotechnology
Volume22
Issue number28
DOIs
Publication statusPublished - 15 Jul 2011
Externally publishedYes

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry (all)
  • Materials Science (all)
  • Mechanics of Materials
  • Mechanical Engineering
  • Electrical and Electronic Engineering

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