Abstract
Granular and crystalline structures of resistant octenyl succinic anhydride (OSA) modified corn starch were characterized using scanning electron microscopy (SEM), optical microscopy and X-ray diffraction. As a colon-targeted delivery carrier, the releasing property of resistant OSA-modified starch was also investigated by In-vitro model. Enhanced succinylation of starch considerably increased the enzyme and acid resistibility to digestion, indicating the improvement of starch colon-targeting property as the degree of substitution (DS) increased. From In-vitro releasing assay, the resistant OSA-modified corn starch based matrix tablets could deliver bioactive components to the colon when the RS content and hydrophobicity were suitable. The relationship between the structure and In-vitro release properties of resistant OSA-modified corn starch suggests that an optimal DS and crystalline:amorphous ratio can be responsible for 5-ASA release. The matrix tablets used resistant OSA-modified corn starch with moderate DS (0.60) and V-type crystal morphology co-exist with the amorphous structure as carrier show good colon-targeted releasing properties.
Original language | English |
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Pages (from-to) | 246-252 |
Number of pages | 7 |
Journal | Food Research International |
Volume | 47 |
Issue number | 2 |
DOIs | |
Publication status | Published - Jul 2012 |
Externally published | Yes |
Keywords
- Bioactive food components
- Colon-targeted delivery
- Octenyl-succinate modification
- Resistant starch
ASJC Scopus subject areas
- Food Science