Streptomyces sp.—a treasure trove of weapons to combat methicillin-resistant staphylococcus aureus biofilm associated with biomedical devices

Priyia Pusparajah, Vengadesh Letchumanan, Jodi Woan Fei Law, Nurul Syakima Ab Mutalib, Yong Sze Ong, Bey Hing Goh, Loh Teng Hern Tan, Learn Han Lee

Research output: Journal PublicationReview articlepeer-review

19 Citations (Scopus)

Abstract

Biofilms formed by methicillin-resistant S. aureus (MRSA) are among the most frequent causes of biomedical device-related infection, which are difficult to treat and are often persistent and recurrent. Thus, new and effective antibiofilm agents are urgently needed. In this article, we review the most relevant literature of the recent years reporting on promising anti-MRSA biofilm agents derived from the genus Streptomyces bacteria, and discuss the potential contribution of these newly reported antibiofilm compounds to the current strategies in preventing biofilm formation and eradicating pre-existing biofilms of the clinically important pathogen MRSA. Many efforts are evidenced to address biofilm-related infections, and some novel strategies have been developed and demonstrated encouraging results in preclinical studies. Nevertheless, more in vivo studies with appropriate biofilm models and well-designed multicenter clinical trials are needed to assess the prospects of these strategies.

Original languageEnglish
Article number9360
JournalInternational Journal of Molecular Sciences
Volume22
Issue number17
DOIs
Publication statusPublished - 1 Sept 2021
Externally publishedYes

Keywords

  • Anti-MRSA
  • Antibiofilm
  • Biofilm-associated infection
  • Medical device
  • Methicillin-resistant
  • Staphylococcus aureus
  • Streptomyces

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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