TY - JOUR
T1 - Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation
AU - UK BiLEVE
AU - Artigas, María Soler
AU - Wain, Louise V.
AU - Miller, Suzanne
AU - Kheirallah, Abdul Kader
AU - Huffman, Jennifer E.
AU - Ntalla, Ioanna
AU - Shrine, Nick
AU - Obeidat, Ma'en
AU - Trochet, Holly
AU - McArdle, Wendy L.
AU - Alves, Alexessander Couto
AU - Hui, Jennie
AU - Zhao, Jing Hua
AU - Joshi, Peter K.
AU - Teumer, Alexander
AU - Albrecht, Eva
AU - Imboden, Medea
AU - Rawal, Rajesh
AU - Lopez, Lorna M.
AU - Marten, Jonathan
AU - Enroth, Stefan
AU - Surakka, Ida
AU - Polasek, Ozren
AU - Lyytikäinen, Leo Pekka
AU - Granell, Raquel
AU - Hysi, Pirro G.
AU - Flexeder, Claudia
AU - Mahajan, Anubha
AU - Beilby, John
AU - Bossé, Yohan
AU - Brandsma, Corry Anke
AU - Campbell, Harry
AU - Gieger, Christian
AU - Gläser, Sven
AU - González, Juan R.
AU - Grallert, Harald
AU - Hammond, Chris J.
AU - Harris, Sarah E.
AU - Hartikainen, Anna Liisa
AU - Heliövaara, Markku
AU - Henderson, John
AU - Hocking, Lynne
AU - Horikoshi, Momoko
AU - Hutri-Kähönen, Nina
AU - Ingelsson, Erik
AU - Johansson, Åsa
AU - Kemp, John P.
AU - Kolcic, Ivana
AU - Kumar, Ashish
AU - Hubbard, Richard
PY - 2015/12/4
Y1 - 2015/12/4
N2 - Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P<5 × 10-8) in or near ENSA, RNU5F-1, KCNS3, AK097794, ASTN2, LHX3, CCDC91, TBX3, TRIP11, RIN3, TEKT5, LTBP4, MN1 and AP1S2, and two novel signals at known loci NPNT and GPR126, providing a basis for new understanding of the genetic determinants of these traits and pulmonary diseases in which they are altered.
AB - Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P<5 × 10-8) in or near ENSA, RNU5F-1, KCNS3, AK097794, ASTN2, LHX3, CCDC91, TBX3, TRIP11, RIN3, TEKT5, LTBP4, MN1 and AP1S2, and two novel signals at known loci NPNT and GPR126, providing a basis for new understanding of the genetic determinants of these traits and pulmonary diseases in which they are altered.
UR - http://www.scopus.com/inward/record.url?scp=84949293492&partnerID=8YFLogxK
U2 - 10.1038/ncomms9658
DO - 10.1038/ncomms9658
M3 - Article
C2 - 26635082
AN - SCOPUS:84949293492
SN - 2041-1723
VL - 6
JO - Nature Communications
JF - Nature Communications
M1 - 8658
ER -
