Sertraline racemate and enantiomer: Solid-state characterization, binary phase diagram, and crystal structures

Quan He, Sohrab Rohani, Jesse Zhu, Hassan Gomaa

Research output: Journal PublicationArticlepeer-review

9 Citations (Scopus)

Abstract

The racemate and enantiomer of sertraline free base were prepared and characterized. The crystalline sertraline enantiomer is relatively less polymorphic compared with the sertraline-HCl salt. The solid-state nature of sertraline racemate was identified to be a racemic compound through a binary melting point phase diagram and spectroscopy analysis. The crystal structures of the racemate and enantiomer were determined to be monoclinic P121/n1 and P21, respectively.

Original languageEnglish
Pages (from-to)1633-1645
Number of pages13
JournalCrystal Growth and Design
Volume10
Issue number4
DOIs
Publication statusPublished - 7 Apr 2010
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry (all)
  • Materials Science (all)
  • Condensed Matter Physics

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