Self-powered, on-demand transdermal drug delivery system driven by triboelectric nanogenerator

Qingling Ouyang, Xueling Feng, Shuangyang Kuang, Nishtha Panwar, Peiyi Song, Chengbin Yang, Guang Yang, Xinya Hemu, Gong Zhang, Ho Sup Yoon, James P. Tam, Bo Liedberg, Guang Zhu, Ken Tye Yong, Zhong Lin Wang

Research output: Journal PublicationArticlepeer-review

55 Citations (Scopus)

Abstract

In this work, we present a self-powered and on-demand transdermal drug delivery system driven by triboelectric nanogenerator (TENG). A miniaturized TENG and a home-built power management circuit were designed to trigger the electric-responsive drug carrier for controlled drug release, as well as to activate the iontophoresis treatment for enhanced drug delivery efficiency. In the system, the TENG can harvest electricity from bio-mechanical energy, and the power management circuit is able to store, adjust, and stabilize the electricity for on-demand drug release actions. Our results demonstrate that the on-demand drug release can be simply realized by operating the TENG. Manually rotating the TENG (30–40 rpm) for 1.5 min can release a drug dosage of 3 μg/cm2. Furthermore, the system has achieved tunable drug release rate for the transdermal drug delivery: the rate can be tuned from 0.05 to 0.25 μg/cm2 per minute by changing the duration of TENG charging or the resistance of the power management circuit. In addition, ex vivo experiments on porcine skin validate the performance of such TENG-based drug delivery system with ∼50% enhancement over conventional transdermal patches. The proposed system is intended to provide patients with an easy approach to achieve customized rate and dosage of drug release.

Original languageEnglish
Pages (from-to)610-619
Number of pages10
JournalNano Energy
Volume62
DOIs
Publication statusPublished - Aug 2019

Keywords

  • On-demand
  • Self-powered
  • Transdermal drug delivery
  • Triboelectric nanogenerator
  • Tunable drug release rate

ASJC Scopus subject areas

  • Renewable Energy, Sustainability and the Environment
  • Materials Science (all)
  • Electrical and Electronic Engineering

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