Satellite nanostructures composed of CdTe quantum dots and DTNB-labeled AuNPs used for SERS-fluorescence dual-signal detection of AFB1

Jinxiang Wei, Yifei He, Zhiyi Song, Imran Mahmood Khan, Zhouping Wang, Caiyun Jiang, Xiaoyuan Ma

Research output: Journal PublicationArticlepeer-review

2 Citations (Scopus)

Abstract

Herein, a surface-enhanced Raman scattering (SERS) and fluorescence dual-signal aptasensor has been developed for aflatoxin B1 (AFB1) detection. Fluorescence signal source CdTe quantum dots were decorated on the outer of silica nanoparticles and further functionalized with AFB1 aptamer. Raman reporter molecules DTNB were decorated on the surface of gold nanoparticles (AuNPs) together with the aptamer complementary chains. The two parts of nanomaterials were combined by the base complementary pairing principle, to form satellite nanostructures with high SERS and low fluorescence signals following LSPR and FRET effect. The addition of AFB1 led to the shedding of AuNPs due to the higher sensitivity of the aptamer towards the target and resulting in recovered fluorescence and decreased SERS signals. The developed method showed a linear relationship in the range of 10−4-103 ng/mL, with detection limit of 0.094 pg/mL. This technology had strong application prospects due to simplicity of operation and high accuracy.

Original languageEnglish
Article number110112
JournalFood Control
Volume156
DOIs
Publication statusPublished - Feb 2024
Externally publishedYes

Keywords

  • Aflatoxin B
  • Aptasensor
  • Dual-signal
  • Fluorescence
  • Surface-enhanced Raman scattering

ASJC Scopus subject areas

  • Biotechnology
  • Food Science

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