Salmonella: A review on pathogenesis, epidemiology and antibiotic resistance

Shu Kee Eng, Priyia Pusparajah, Nurul Syakima Ab Mutalib, Hooi Leng Ser, Kok Gan Chan, Learn Han Lee

Research output: Journal PublicationArticlepeer-review

526 Citations (Scopus)


Salmonella is one of the most frequently isolated foodborne pathogens. It is a major worldwide public health concern, accounting for 93.8 million foodborne illnesses and 155,000 deaths per year. To date, over 2500 Salmonella serotypes have been identified and more than half of them belong to Salmonella enterica subsp. enterica, which accounts for the majority of Salmonella infections in humans. Salmonella infections that involve invasive serotypes are often life threatening, necessitating appropriate and effective antibiotic therapy. The emergence of multi-drug-resistant (MDR) Salmonella serotypes is having a great impact on the efficacy of antibiotic treatment, and an increasing prevalence of MDR strains may lead to an increase in mortality rates of Salmonella infections. Epidemiological studies indicate that MDR Salmonella serotypes are more virulent than susceptible strains, as reflected by increased severity and more prolonged disease in patients infected by MDR strains. Preventive measures have been proposed to eliminate the spread of Salmonella infection. While the maintenance of effective food hygiene and water sanitation remain the cornerstones, additional measures such as restriction of indiscriminate use of antibiotics in food animals are important. This review provides an overview of Salmonella infection, and discusses the nomenclature, pathogenesis, clinical manifestations, epidemiology and antibiotic resistance of Salmonella.

Original languageEnglish
Pages (from-to)284-293
Number of pages10
JournalFrontiers in Life Science
Issue number3
Publication statusPublished - 3 Jul 2015
Externally publishedYes


  • Salmonella
  • enteric fever
  • foodborne
  • multi-drug resistance

ASJC Scopus subject areas

  • General Neuroscience
  • General Biochemistry,Genetics and Molecular Biology


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