TY - JOUR
T1 - Reproducibility of deep learning based scleral spur localisation and anterior chamber angle measurements from anterior segment optical coherence tomography images
AU - Liu, Peng
AU - Higashita, Risa
AU - Guo, Philip Yawen
AU - Okamoto, Keiichiro
AU - Li, Fei
AU - Nguyen, Anwell
AU - Sakata, Rei
AU - Duan, Lixin
AU - Aihara, Makoto
AU - Lin, Shan
AU - Zhang, Xiulan
AU - Leung, Christopher Kai Shun
AU - Liu, Jiang
N1 - Publisher Copyright:
© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
PY - 2022
Y1 - 2022
N2 - Aims: To apply a deep learning model for automatic localisation of the scleral spur (SS) in anterior segment optical coherence tomography (AS-OCT) images and compare the reproducibility of anterior chamber angle (ACA) width between deep learning located SS (DLLSS) and manually plotted SS (MPSS). Methods: In this multicentre, cross-sectional study, a test dataset comprising 5166 AS-OCT images from 287 eyes (116 healthy eyes with open angles and 171 eyes with primary angle-closure disease (PACD)) of 287 subjects were recruited from four ophthalmology clinics. Each eye was imaged twice by a swept-source AS-OCT (CASIA2, Tomey, Nagoya, Japan) in the same visit and one eye of each patient was randomly selected for measurements of ACA. The agreement between DLLSS and MPSS was assessed using the Euclidean distance (ED). The angle opening distance (AOD) of 750 μm (AOD750) and trabecular-iris space area (TISA) of 750 μm (TISA750) were calculated using the CASIA2 embedded software. The repeatability of ACA width was measured. Results: The mean age was 60.8±12.3 years (range: 30-85 years) for the normal group and 63.4±10.6 years (range: 40-91 years) for the PACD group. The mean difference in ED for SS localisation between DLLSS and MPSS was 66.50±20.54 μm and 84.78±28.33 μm for the normal group and the PACD group, respectively. The span of 95% limits of agreement between DLLSS and MPSS was 0.064 mm for AOD750 and 0.034 mm2 for TISA750. The respective repeatability coefficients of AOD750 and TISA750 were 0.049 mm and 0.026 mm2 for DLLSS, and 0.058 mm and 0.030 mm2 for MPSS. Conclusion: DLLSS achieved comparable repeatability compared with MPSS for measurement of ACA.
AB - Aims: To apply a deep learning model for automatic localisation of the scleral spur (SS) in anterior segment optical coherence tomography (AS-OCT) images and compare the reproducibility of anterior chamber angle (ACA) width between deep learning located SS (DLLSS) and manually plotted SS (MPSS). Methods: In this multicentre, cross-sectional study, a test dataset comprising 5166 AS-OCT images from 287 eyes (116 healthy eyes with open angles and 171 eyes with primary angle-closure disease (PACD)) of 287 subjects were recruited from four ophthalmology clinics. Each eye was imaged twice by a swept-source AS-OCT (CASIA2, Tomey, Nagoya, Japan) in the same visit and one eye of each patient was randomly selected for measurements of ACA. The agreement between DLLSS and MPSS was assessed using the Euclidean distance (ED). The angle opening distance (AOD) of 750 μm (AOD750) and trabecular-iris space area (TISA) of 750 μm (TISA750) were calculated using the CASIA2 embedded software. The repeatability of ACA width was measured. Results: The mean age was 60.8±12.3 years (range: 30-85 years) for the normal group and 63.4±10.6 years (range: 40-91 years) for the PACD group. The mean difference in ED for SS localisation between DLLSS and MPSS was 66.50±20.54 μm and 84.78±28.33 μm for the normal group and the PACD group, respectively. The span of 95% limits of agreement between DLLSS and MPSS was 0.064 mm for AOD750 and 0.034 mm2 for TISA750. The respective repeatability coefficients of AOD750 and TISA750 were 0.049 mm and 0.026 mm2 for DLLSS, and 0.058 mm and 0.030 mm2 for MPSS. Conclusion: DLLSS achieved comparable repeatability compared with MPSS for measurement of ACA.
KW - anterior chamber
KW - glaucoma
UR - http://www.scopus.com/inward/record.url?scp=85138799288&partnerID=8YFLogxK
U2 - 10.1136/bjophthalmol-2021-319798
DO - 10.1136/bjophthalmol-2021-319798
M3 - Article
C2 - 35091438
AN - SCOPUS:85138799288
SN - 0007-1161
JO - British Journal of Ophthalmology
JF - British Journal of Ophthalmology
M1 - bjophthalmol-2021-319798
ER -