Regulating the anticancer drug release rate by controlling the composition of waterborne polyurethane

Ali Bahadur, Muhammad Shoaib, Shahid Iqbal, Aamer Saeed, Muhamad Saif ur Rahman, Pervaiz Ali Channar

Research output: Journal PublicationArticlepeer-review

36 Citations (Scopus)


Water-based polyurethane (WPU) is an alternate green pathway which poses a minimum threat to the environment. In WPU, hard segments (HS) and soft segments (SS) have a pronounced effect on the physicochemical properties of the polymer. Therefore, the effect of a change in the size of HS and SS on the properties of WPU were studied in detailed. Size of HS and SS were varied by increasing the aliphatic chain length of chain extender and PEG respectively. WPU were prepared with different compositions and the effect on thermal stability, mechanical properties, chemical resistance, biodegradation, biocompatibility, the degree of swelling, and drug release rate was studied. For this purpose, two series of WPU were synthesized to study structure–property relationship. The first series of WPU were synthesized by varying molecular weights of polyethylene diol (PEG, Mn = 650, 1250, 1500, and 2000 g/mol) and the second series was synthesized by using diamine chain extenders (CE) with increasing aliphatic chain. All WPU did not show any cytotoxicity as evaluated by MTT assay and are designated as safe biomaterials.

Original languageEnglish
Pages (from-to)134-141
Number of pages8
JournalReactive and Functional Polymers
Publication statusPublished - Oct 2018
Externally publishedYes


  • 5-Fluorouracil
  • Drug delivery
  • Polyurethane
  • Sustained release
  • Waterborne

ASJC Scopus subject areas

  • Chemistry (all)
  • Environmental Chemistry
  • Biochemistry
  • Chemical Engineering (all)
  • Polymers and Plastics
  • Materials Chemistry


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