Presence of a prothrombotic state in people with idiopathic pulmonary fibrosis: A population-based case-control study

Vidya Navaratnam, Andrew W. Fogarty, Tricia McKeever, Norma Thompson, Gisli Jenkins, Simon R. Johnson, Gerard Dolan, Maruti Kumaran, Kate Pointon, Richard B. Hubbard

Research output: Journal PublicationArticlepeer-review

74 Citations (Scopus)

Abstract

Background: Laboratory studies suggest that the clotting cascade is activated in fibrotic lungs. Since humans vary in their tendency to clot due to a variety of inherited or acquired defects, we investigated whether a prothrombotic state increases the chance of developing idiopathic pulmonary fibrosis (IPF) and/or worsens the prognosis of IPF. Methods: We recruited 211 incident cases of IPF and 256 age- and sex-matched general population controls and collected data on medical history, medication, smoking habit, blood samples as well as lung function and high-resolution CT scans done as part of routine clinical care. A prothrombotic state was defined as the presence of at least one inherited or acquired clotting defect or marker of fibrinolytic dysfunction. We used logistic regression to quantify the association between a prothrombotic state and IPF adjusted for age, sex, smoking habit and highly sensitive C reactive protein. Cox regression was used to determine the influence of a prothrombotic state on survival. Results: Cases were more than four times more likely than controls to have a prothrombotic state (OR 4.78, 95% CI 2.93 to 7.80; p<0.0001). Cases with a prothrombotic state were also likely to have more severe disease (forced vital capacity <70% predicted) at presentation (OR 10.79, 95% CI 2.43 to 47.91) and had a threefold increased risk of death (HR 3.26, 95% CI 1.09 to 9.75). Conclusions: People with IPF are more likely to have a prothrombotic state than general population controls and the presence of a prothrombotic state has an adverse impact on survival.

Original languageEnglish
Pages (from-to)207-215
Number of pages9
JournalThorax
Volume69
Issue number3
DOIs
Publication statusPublished - Mar 2014
Externally publishedYes

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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