Preparation and characterization of curcumin/chitosan conjugate as an efficient photodynamic antibacterial agent

Lingyu Zhao, Xiaowei Ding, Imran Mahmood Khan, Lin Yue, Yin Zhang, Zhouping Wang

Research output: Journal PublicationArticlepeer-review

15 Citations (Scopus)

Abstract

Curcumin (Cur) is a natural pigment with excellent biological activity. The poor stability and insolubility of Cur in water severely limit its application. Therefore, to overcome these dilemmas which are big hindrances in their application, a novel derivative (COCS-Cur) was prepared by the esterification reaction of carboxylated chitosan (COCS) and Cur. The structure and properties of conjugate were determined through a series of characterizations. The derivatives had excellent solubility as well as stability. In addition, antioxidant and photodynamic antibacterial experiments proved that COCS-Cur had the excellent free radical scavenging ability and photodynamic antibacterial activity. The derivatives presented a better antibacterial effect on Staphylococcus aureus (S. aureus) than Escherichia coli (E. coli). Noteworthy, the COCS-Cur derivatives showed no obvious toxicity which makes them a stronger contender and potential antimicrobial agent or functional nutrient for application in the food industry.

Original languageEnglish
Article number120852
JournalCarbohydrate Polymers
Volume313
DOIs
Publication statusPublished - 1 Aug 2023
Externally publishedYes

Keywords

  • Antioxidant activity
  • Chitosan
  • Curcumin
  • Photodynamic sterilization
  • Stability
  • Water solubility

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

Fingerprint

Dive into the research topics of 'Preparation and characterization of curcumin/chitosan conjugate as an efficient photodynamic antibacterial agent'. Together they form a unique fingerprint.

Cite this