Potassium tert-butoxide promoted regioselective deuteration of pyridines

Yan Li, Chenxu Zheng, Zhi Jiang Jiang, Jianbo Tang, Bencan Tang, Zhanghua Gao

Research output: Journal PublicationArticlepeer-review

7 Citations (Scopus)


A regioselective deuteration at the β- and γ-position of pyridines is reported. Efficient deuteration occurred with a combination of KOtBu and DMSO-d6, replenishing the prevailing α-deuteration of the pyridine systems. Preliminary mechanistic studies suggested that the dimsyl carbanion acts as one of the key intermediates.

Original languageEnglish
Pages (from-to)3497-3500
Number of pages4
JournalChemical Communications
Issue number21
Publication statusPublished - 14 Feb 2022

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry (all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry


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