Posterior capsule opacification

Research output: Chapter in Book/Conference proceedingBook Chapterpeer-review

1 Citation (Scopus)

Abstract

Posterior capsule opacification (PCO), also known as after-cataract and secondary cataract, is the most prevalent complication following cataract surgery. The basis of the condition is a pronounced wound-healing response from residual lens epithelial cells, which colonize the lens posterior capsule, deform the matrix, and form cell aggregates. This ultimately leads to light scatter within the visual axis. An artificial lens is routinely introduced at surgery; improved designs have reduced the incidence of PCO, but the problem still remains significant. In this article, our knowledge of the biological basis of PCO and methods to manage the problem will be discussed.

Original languageEnglish
Title of host publicationEncyclopedia of the Eye
PublisherElsevier
Pages469-475
Number of pages7
ISBN (Electronic)9780123742032
ISBN (Print)9780123741981
DOIs
Publication statusPublished - 1 Jan 2010
Externally publishedYes

Keywords

  • After-cataract
  • Contraction
  • Differentiation
  • EMT
  • Growth factors
  • Intraocular lens
  • Lens
  • Matrix
  • Migration
  • Posterior capsule opacification
  • Proliferation
  • Secondary cataract
  • Transdifferentiation

ASJC Scopus subject areas

  • General Medicine

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