New technologies for vaccine development

Kellathur N. Srinivasan; Vladimir Brusic; Thomas J. August

doi:10.1002/ddr.10393

New technologies for vaccine development

Kellathur N. Srinivasan, Vladimir Brusic, Thomas J. August

Research output: Journal Publication › Article › peer-review

10 Citations (Scopus)

Abstract

(Table Presented) Vaccines offer protection against infectious diseases, but the successes from the years of development have been mixed. Some diseases have been effectively controlled or eradicated through vaccination, whereas treatments for a number of diseases, especially the reemerging diseases, currently do not exist. Improved understanding of pathogen variability as well as of the diversity of the human immune system, plus technological advances in genetic and molecular biology provide better insights in the host-pathogen interaction and new avenues for vaccine development. In this article we discuss the latest trends in vaccine research with focus on epitope-based DNA vaccines and trafficking components for efficient vaccine delivery. These approaches are promising in dealing with host and pathogen diversity as well as with diversity within human populations.

Original language	English
Pages (from-to)	383-392
Number of pages	10
Journal	Drug Development Research
Volume	62
Issue number	4
DOIs	https://doi.org/10.1002/ddr.10393
Publication status	Published - Aug 2004
Externally published	Yes

Keywords

Bioinformatics
Hot spots
T-cell epitopes
Vaccines

ASJC Scopus subject areas

Drug Discovery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/ddr.10393

Cite this

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title = "New technologies for vaccine development",

abstract = "(Table Presented) Vaccines offer protection against infectious diseases, but the successes from the years of development have been mixed. Some diseases have been effectively controlled or eradicated through vaccination, whereas treatments for a number of diseases, especially the reemerging diseases, currently do not exist. Improved understanding of pathogen variability as well as of the diversity of the human immune system, plus technological advances in genetic and molecular biology provide better insights in the host-pathogen interaction and new avenues for vaccine development. In this article we discuss the latest trends in vaccine research with focus on epitope-based DNA vaccines and trafficking components for efficient vaccine delivery. These approaches are promising in dealing with host and pathogen diversity as well as with diversity within human populations.",

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AU - Srinivasan, Kellathur N.

AU - Brusic, Vladimir

AU - August, Thomas J.

PY - 2004/8

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N2 - (Table Presented) Vaccines offer protection against infectious diseases, but the successes from the years of development have been mixed. Some diseases have been effectively controlled or eradicated through vaccination, whereas treatments for a number of diseases, especially the reemerging diseases, currently do not exist. Improved understanding of pathogen variability as well as of the diversity of the human immune system, plus technological advances in genetic and molecular biology provide better insights in the host-pathogen interaction and new avenues for vaccine development. In this article we discuss the latest trends in vaccine research with focus on epitope-based DNA vaccines and trafficking components for efficient vaccine delivery. These approaches are promising in dealing with host and pathogen diversity as well as with diversity within human populations.

AB - (Table Presented) Vaccines offer protection against infectious diseases, but the successes from the years of development have been mixed. Some diseases have been effectively controlled or eradicated through vaccination, whereas treatments for a number of diseases, especially the reemerging diseases, currently do not exist. Improved understanding of pathogen variability as well as of the diversity of the human immune system, plus technological advances in genetic and molecular biology provide better insights in the host-pathogen interaction and new avenues for vaccine development. In this article we discuss the latest trends in vaccine research with focus on epitope-based DNA vaccines and trafficking components for efficient vaccine delivery. These approaches are promising in dealing with host and pathogen diversity as well as with diversity within human populations.

KW - Bioinformatics

KW - Hot spots

KW - T-cell epitopes

KW - Vaccines

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SP - 383

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JO - Drug Development Research

JF - Drug Development Research

IS - 4

ER -

New technologies for vaccine development

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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