Naloxone blocks the release of opioid peptides in periaqueductal gray and N. accumbens induced by intra-amygdaloid injection of morphine

Q. P. Ma, J. S. Han

Research output: Journal PublicationArticlepeer-review

18 Citations (Scopus)

Abstract

The working hypothesis that the periaqueductal gray (PAG), N. accumbens and amygdala were connected serially in a unidirectional loop for antinociception, in which Met-enkephalin and β-endorphin were considered to be two important analgesic neurotransmitters, was examined by simultaneously perfusing the PAG and N. accumbens after microinjection of morphine into the amygdala. Intra-amygdaloid injection of morphine increased the release of enkephalins and β-endorphin in the PAG and N. accumbens. When the perfusion fluid contained 3 μM of naloxone, the release of enkephalins and β-endorphin was reduced in both the PAG and the N. accumbens. These results do not support the hypothesis of a unidirectional loop and its putative sequence.

Original languageEnglish
Pages (from-to)1235-1238
Number of pages4
JournalPeptides
Volume12
Issue number6
DOIs
Publication statusPublished - 1991
Externally publishedYes

Keywords

  • Amygdala
  • Morphine
  • Nucleus accumbens
  • Opioid peptides
  • Periaqueductal gray

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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