Mycobacterium ulcerans and Mycobacterium marinum: Pathogenesis, Diagnosis and Treatment

Loh Teng Hern Tan, Pendru Raghunath, Long Chiau Ming, Jodi Woan Fei Law

Research output: Journal PublicationArticlepeer-review

6 Citations (Scopus)


Skin and soft tissue infections are common presentations for non-tuberculous mycobacteria (NTM). The cutaneous infections caused by NTM may cause localized or diffuse lesions. M. ulcerans is one of the most identified pathogens that involves in the skin and soft tissue mycobacterial infections. Meanwhile, M. marinum, as an NTM has also become important emerging causal agents of cutaneous disease in various geographical regions. Although having common ancestry and highly similar in genetic makeup, M. ulcerans and M. marinum have differential impacts on the host innate immune system. In term pathogenesis, prolonged cell exposure to exotoxin mycolactone produced by M. ulcerans could lead to Buruli ulcer. Meanwhile, like most pathogenic mycobacteria, M. marinum evades the host immune responses by invading and replicating inside host cells and it is capable of modulating host immune responses. This article aims to provide a general overview and comparisons between the pathogenesis, diagnosis, prevention and therapeutic strategies for M. ulcerans and M. marinum.

Original languageEnglish
Article numbera0000114
JournalProgress in Microbes and Molecular Biology
Issue number1
Publication statusPublished - 6 Feb 2020
Externally publishedYes


  • Mycobacterium marinum
  • Mycobacterium ulcerans
  • diagnosis
  • pathogenesis
  • treatment

ASJC Scopus subject areas

  • Molecular Biology
  • Microbiology (medical)
  • Microbiology
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)


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