Mineral metabolism and ferroptosis in non-alcoholic fatty liver diseases

Chenhui Ma, Li Han, Zheying Zhu, Cheng Heng Pang, Guoyu Pan

Research output: Journal PublicationReview articlepeer-review

Abstract

Nonalcoholic fatty liver disease (NAFLD) has become the most prevalent chronic liver disease worldwide. Minerals including iron, copper, zinc, and selenium, fulfil an essential role in various biochemical processes. Moreover, the identification of ferroptosis and cuproptosis further underscores the importance of intracellular mineral homeostasis. However, perturbation of minerals has been frequently reported in patients with NAFLD and related diseases. Interestingly, studies have attempted to establish an association between mineral disorders and NAFLD pathological features, including oxidative stress, mitochondrial dysfunction, inflammatory response, and fibrogenesis. In this review, we aim to provide an overview of the current understanding of mineral metabolism (i.e., absorption, utilization, and transport) and mineral interactions in the pathogenesis of NAFLD. More importantly, this review highlights potential therapeutic strategies, challenges, future directions for targeting mineral metabolism in the treatment of NAFLD.

Original languageEnglish
Article number115242
JournalBiochemical Pharmacology
Volume205
DOIs
Publication statusPublished - Nov 2022

Keywords

  • Copper
  • Ferroptosis
  • Iron
  • Mineral
  • Non-alcoholic fatty liver disease
  • Non-alcoholic steatohepatitis

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology

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