Mangrove derived Streptomyces sp. MUM265 as a potential source of antioxidant and anticolon-cancer agents

Loh Teng Hern Tan, Kok Gan Chan, Priyia Pusparajah, Wai Fong Yin, Tahir Mehmood Khan, Learn Han Lee, Bey Hing Goh

Research output: Journal PublicationArticlepeer-review

57 Citations (Scopus)

Abstract

Background: Colon cancer is the third most commonly diagnosed cancer worldwide, with a commensurately high mortality rate. The search for novel antioxidants and specific anticancer agents which may inhibit, delay or reverse the development of colon cancer is thus an area of great interest; Streptomyces bacteria have been demonstrated to be a source of such agents. Results: The extract from Streptomyces sp. MUM265 - a strain which was isolated and identified from Kuala Selangor mangrove forest, Selangor, Malaysia - was analyzed and found to exhibit antioxidant properties as demonstrated via metal-chelating ability as well as superoxide anion, DPPH and ABTS radical scavenging activities. This study also showed that MUM265 extract demonstrated cytotoxicity against colon cancer cells as evidenced by the reduced cell viability of Caco-2 cell line. Treatment with MUM265 extract induced depolarization of mitochondrial membrane potential and accumulation of subG 1 cells in cell cycle analysis, suggesting that MUM265 exerted apoptosis-inducing effects on Caco-2 cells. Conclusion: These findings indicate that mangrove derived Streptomyces sp. MUM265 represents a valuable bioresource of bioactive compounds for the future development of chemopreventive agents, with particular promise suggested for treatment of colon cancer.

Original languageEnglish
Article number38
JournalBMC Microbiology
Volume19
Issue number1
DOIs
Publication statusPublished - 13 Feb 2019
Externally publishedYes

Keywords

  • Antioxidant
  • Colon cancer
  • Cytotoxic
  • Mangroves
  • Streptomyces

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

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