Level-set based automatic cup-to-disc ratio determination using retinal fundus images in argali

D. W.K. Wong, J. Liu, J. H. Lim, X. Jia, F. Yin, H. Li, T. Y. Wong

Research output: Chapter in Book/Conference proceedingConference contributionpeer-review

160 Citations (Scopus)

Abstract

Glaucoma is a leading cause of permanent blindness. However, disease progression can be limited if detected early. The optic cup-to-disc ratio (CDR) is one of the main clinical indicators of glaucoma, and is currently determined manually, limiting its potential in mass screening. In this paper, we propose an automatic CDR determination method using a variational level-set approach to segment the optic disc and cup from retinal fundus images. The method is a core component of ARGALI, a system for automated glaucoma risk assessment. Threshold analysis is used in preprocessing to estimate the initial contour. Due to the presence of retinal vasculature traversing the disc and cup boundaries which can cause inaccuracies in the detected contours, an ellipse-fitting post-processing step is also introduced. The method was tested on 104 images from the Singapore Malay Eye Study, and it was found the results produced a clinically acceptable variation of up to 0.2 CDR units from the manually graded samples, with potential use in mass screening.

Original languageEnglish
Title of host publicationProceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08
PublisherIEEE Computer Society
Pages2266-2269
Number of pages4
ISBN (Print)9781424418152
DOIs
Publication statusPublished - 2008
Externally publishedYes
Event30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - Vancouver, BC, Canada
Duration: 20 Aug 200825 Aug 2008

Publication series

NameProceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology"

Conference

Conference30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08
Country/TerritoryCanada
CityVancouver, BC
Period20/08/0825/08/08

Keywords

  • Automated level-set segmentation
  • Medical image processing
  • Optic cup-to-disc ratio

ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Signal Processing
  • Biomedical Engineering
  • Health Informatics

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