TY - JOUR
T1 - ImmunoGrid, an integrative environment for large-scale simulation of the immune system for vaccine discovery, design and optimization
AU - Pappalardo, Francesco
AU - Halling-Brown, Mark D.
AU - Rapin, Nicolas
AU - Zhang, Ping
AU - Alemani, Davide
AU - Emerson, Andrew
AU - Paci, Paola
AU - Duroux, Patrice
AU - Pennisi, Marzio
AU - Palladini, Arianna
AU - Miotto, Olivo
AU - Churchill, Daniel
AU - Rossi, Elda
AU - Shepherd, Adrian J.
AU - Moss, David S.
AU - Castiglione, Filippo
AU - Bernaschi, Massimo
AU - Lefranc, Marie Paule
AU - Brunak, Søren
AU - Motta, Santo
AU - Lollini, Pier Luigi
AU - Basford, Kaye E.
AU - Brusic, Vladimir
PY - 2009
Y1 - 2009
N2 - Vaccine research is a combinatorial science requiring computational analysis of vaccine components, formulations and optimization. We have developed a framework that combines computational tools for the study of immune function and vaccine development. This framework, named ImmunoGrid combines conceptual models of the immune system, models of antigen processing and presentation, system-level models of the immune system, Grid computing, and database technology to facilitate discovery, formulation and optimization of vaccines. ImmunoGrid modules share common conceptual models and ontologies. The ImmunoGrid portal offers access to educational simulators where previously defined cases can be displayed, and to research simulators that allow the development of new, or tuning of existing, computational models. The portal is accessible at 〈igrid-ext.cryst.bbk.ac.uk/immunogrid〉.
AB - Vaccine research is a combinatorial science requiring computational analysis of vaccine components, formulations and optimization. We have developed a framework that combines computational tools for the study of immune function and vaccine development. This framework, named ImmunoGrid combines conceptual models of the immune system, models of antigen processing and presentation, system-level models of the immune system, Grid computing, and database technology to facilitate discovery, formulation and optimization of vaccines. ImmunoGrid modules share common conceptual models and ontologies. The ImmunoGrid portal offers access to educational simulators where previously defined cases can be displayed, and to research simulators that allow the development of new, or tuning of existing, computational models. The portal is accessible at 〈igrid-ext.cryst.bbk.ac.uk/immunogrid〉.
KW - Computational modeling
KW - Grid computing
KW - Immunoinformatics
KW - Simulations
KW - Vaccine discovery
UR - http://www.scopus.com/inward/record.url?scp=65549157113&partnerID=8YFLogxK
U2 - 10.1093/bib/bbp014
DO - 10.1093/bib/bbp014
M3 - Article
C2 - 19383844
AN - SCOPUS:65549157113
SN - 1467-5463
VL - 10
SP - 330
EP - 340
JO - Briefings in Bioinformatics
JF - Briefings in Bioinformatics
IS - 3
ER -
