Heliaquanoids A-E, Five Sesquiterpenoid Dimers from Inula helianthus-aquatica

Zai Qin Zheng, Wen Jun Wei, Junmin Zhang, Hang Ying Li, Kai Xu, Jiayuan Xu, Bencan Tang, Ya Li, Kun Gao

Research output: Journal PublicationArticlepeer-review

10 Citations (Scopus)
3 Downloads (Pure)

Abstract

Heliaquanoid A (1), the first exo-2,4-linked Diels-Alder adduct between a pseudoguaianolide dienophile and a guaianolide diene, and heliaquanoids B-E (2-5), four new 2,4-linked Diels-Alder adducts between a xanthanolide dienophile and a guaianolide diene, were isolated from stems and leaves of Inula helianthus-aquatica. Their structures were determined by NMR spectroscopy, a modified Mosher's method, electronic circular dichroism, and X-ray diffraction analysis. Compounds 2 and 3 exhibited moderate cytotoxic activities against HL-60 cells with IC50 values of 7.5 and 4.9 μM, respectively.

Original languageEnglish
Pages (from-to)4473-4477
Number of pages5
JournalJournal of Organic Chemistry
Volume84
Issue number7
DOIs
Publication statusPublished - 5 Apr 2019

ASJC Scopus subject areas

  • Organic Chemistry

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