Further studies on interactions between periaqueductal gray, nucleus accumbens and habenula in antinociception

Qing Ping Ma, Yu Shun Shi, Ji Sheng Han

Research output: Journal PublicationArticlepeer-review

45 Citations (Scopus)

Abstract

Previous findings from this laboratory with the intracerebral microinjection technique suggested that the periaqueductal gray (PAG), nucleus accumbens, and habenula might constitute a unidirectional loop to play their roles in pain modulation. In the present study we demonstrate that intra-habenular injection of naloxone antagonizes the analgesia elicited by morphine injected into the periaqueductal gray (PAG) and that intra-accumbens injection of naloxone is capable of attenuating the analgesic effects of morphine injected into the habenula. These results indicate that the relationships between these nuclei may be more complex than the putative unidirectional loop.

Original languageEnglish
Pages (from-to)292-295
Number of pages4
JournalBrain Research
Volume583
Issue number1-2
DOIs
Publication statusPublished - 1992
Externally publishedYes

Keywords

  • Analgesia
  • Habenula
  • Morphine
  • Naloxone
  • Nucleus accumbens
  • Periaqueductal gray

ASJC Scopus subject areas

  • Neuroscience (all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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