Flexible paper-based SERS substrate strategy for rapid detection of methyl parathion on the surface of fruit

Jie Xie, Liangyu Li, Imran Mahmood Khan, Zhouping Wang, Xiaoyuan Ma

Research output: Journal PublicationArticlepeer-review

56 Citations (Scopus)


Herein, we reported a simple, flexible and sensitive surface-enhanced Raman scattering (SERS) substrate to detect methyl parathion residues in real life. The substrate was fabricated by filter paper and gold nanoparticles (Au NPs) with excellent reproducibility and stability. First, Au NPs were synthesized by the seed mediated growth method and assembled to the filter paper through immersion. The Raman probe molecule 4-MBA was used to evaluate performance of the substrate for an optimized signal using a portable Raman spectrometer coupled with 785 nm laser. Then, the paper-based substrate was applied to detect methyl parathion standard solution whose detection limit was down to 0.011 μg/cm2, and the linear range was between 0.018 μg/cm2 and 0.354 μg/cm2. Afterwards, actual sample (apple) spiked with methyl parathion was taken to verify the practicality of the substrate by a simple way of “press–peel off”. The recovery rate was ranged from 94.09% to 98.72%, indicating that this method is reliable in actual sample detection without complicated pretreatment steps. This work demonstrates that the flexible paper-based substrate combined with portable Raman instruments can be potentially applied to on-site detection of hazardous substances in the field of food safety.

Original languageEnglish
Article number118104
JournalSpectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
Publication statusPublished - 15 Apr 2020
Externally publishedYes


  • Au NPs
  • Methyl parathion
  • SERS
  • The paper-based substrate

ASJC Scopus subject areas

  • Analytical Chemistry
  • Atomic and Molecular Physics, and Optics
  • Instrumentation
  • Spectroscopy


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