Facile synthesis and antibacterial activity of geraniol conjugated chitosan oligosaccharide derivatives

Ran Bi, Lin Yue, Sobia Niazi, Imran Mahmood Khan, Dan Sun, Bin Wang, Zhouping Wang, Qixing Jiang, Wenshui Xia

Research output: Journal PublicationArticlepeer-review

59 Citations (Scopus)


A new chitosan oligosaccharide derivative (COS-N-Ger), based on geraniol (Ger) modificated onto the NH2 position of chitosan oligosaccharide (COS) via a facile method, was prepared and employed to evaluate in vitro antibacterial activity. The structures of COS-N-Ger derivatives were confirmed by FT-IR, 1H, 13C NMR, and elemental analysis. The characterization results showed successful synthesis of derivatives and the degrees of substitution (DS) of COS-N-Ger1-3 were from 0.260 to 0.283 with the yields up to 78 %. The in vitro antibacterial activity evaluation results presented a significant inhibition effect of COS-N-Ger1-3 derivatives on Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) as compared to COS. Moreover, their antibacterial activities were dose-dependent and more sensitive to S. aureus than E. coli. The results provide reliable theoretical supports for exploring the application of COS derivatives in the food industry as new potential antibacterial agents.

Original languageEnglish
Article number117099
JournalCarbohydrate Polymers
Publication statusPublished - 1 Jan 2021
Externally publishedYes


  • Antibacterial activity
  • Chitosan oligosaccharide
  • Modification

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry


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