Facile stoichiometric reductions in flow: An example of artemisinin

Xiaolei Fan, Victor Sans, Polina Yaseneva, Dorota D. Plaza, Jonathan Williams, Alexei Lapkin

Research output: Journal PublicationArticlepeer-review

38 Citations (Scopus)

Abstract

Stoichiometric reduction of artemisinin to dihydroartemisinin (DHA) has been successfully transferred from batch to continuous flow conditions with a significant increase in productivity and an increase in selectivity. The DHA space-time-yield of up to 1.6 kg h -1 L -1 was attained which represents a 42 times increase in throughput compared to that of conventional batch process.

Original languageEnglish
Pages (from-to)1039-1042
Number of pages4
JournalOrganic Process Research and Development
Volume16
Issue number5
DOIs
Publication statusPublished - 18 May 2012
Externally publishedYes

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry

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