Fabrication of polyhydroxybutyrate (PHB)/γ-Fe2O3 nanocomposite film and its properties study

Shokooh Moghaddam, Mohammad Taghi Khorasani, Hesam Hosseinkazemi, Esmaeil Biazar, Mahyar Fazeli

Research output: Journal PublicationArticlepeer-review

9 Citations (Scopus)

Abstract

Magnetic separation has numerous advantages in isolating cancerous and normal cells used in the diagnosis and treatment sectors. Here, we produced magnetic nanocomposite films made of polyhydroxybutyrate (PHB)/magnetite nanoparticles (γ-Fe2O3), and the properties of the films by SEM, TEM, FTIR, DMTA, contact angle, and cellular analyses were investigated. The microscopic images showed uniform distribution of γ-Fe2O3 magnetic nanoparticles in polymeric matrix. The chemical bounds between magnetic nanoparticles and polymeric matrix demonstrated using the FTIR spectrophotometer. The DMTA and contact angle results indicated an increase in the glass transition temperature and hydrophilic properties of nanocomposites is achieved by increasing the magnetic nanoparticles amount in polymer matrix. The cellular results were showed that adhesion of cancer cells compared to normal cells was significantly enhanced by the induction of a magnetic field. These nanocomposite films can be used as a substrate for cellular adhesion and separation processes.

Original languageEnglish
Pages (from-to)793-804
Number of pages12
JournalJournal of Biomaterials Science, Polymer Edition
Volume27
Issue number9
DOIs
Publication statusPublished - 12 Jun 2016
Externally publishedYes

Keywords

  • cell separation
  • Magnetic nanocomposite
  • physical and mechanical analyses
  • polyhydroxybuthyrate (PHB)
  • γ-FeO nanoparticles

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

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