Extraction of bioactives from Orthosiphon stamineus using microwave and ultrasound-assisted techniques: Process optimization and scale up

Chung Hung Chan, Tiam You See, Rozita Yusoff, Gek Cheng Ngoh, Kien Woh Kow

Research output: Journal PublicationArticlepeer-review

35 Citations (Scopus)

Abstract

This work demonstrated the optimization and scale up of microwave-assisted extraction (MAE) and ultrasonic-assisted extraction (UAE) of bioactive compounds from Orthosiphon stamineus using energy-based parameters such as absorbed power density and absorbed energy density (APD-AED) and response surface methodology (RSM). The intensive optimum conditions of MAE obtained at 80% EtOH, 50 mL/g, APD of 0.35 W/mL, AED of 250 J/mL can be used to determine the optimum conditions of the scale-dependent parameters i.e. microwave power and treatment time at various extraction scales (100–300 mL solvent loading). The yields of the up scaled conditions were consistent with less than 8% discrepancy and they were about 91–98% of the Soxhlet extraction yield. By adapting APD-AED method in the case of UAE, the intensive optimum conditions of the extraction, i.e. 70% EtOH, 30 mL/g, APD of 0.22 W/mL, AED of 450 J/mL are able to achieve similar scale up results.

Original languageEnglish
Pages (from-to)1382-1387
Number of pages6
JournalFood Chemistry
Volume221
DOIs
Publication statusPublished - 15 Apr 2017
Externally publishedYes

Keywords

  • Bioactive compounds
  • Microwave extraction
  • Orthosiphon stamineus
  • Scale up
  • Ultrasonic extraction

ASJC Scopus subject areas

  • Analytical Chemistry
  • Food Science

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