Excited state dependent electron transfer of a rhenium-dipyridophenazine complex intercalated between the base pairs of DNA: A time-resolved UV-visible and IR absorption investigation into the photophysics of fac-[Re(CO) 3(F2dppz)(py)]+ bound to either [poly(dA-dT)]2 or [poly(dG-dC)]2

Qian Cao; Caitriona M. Creely; E. Stephen Davies; Joanne Dyer; Timothy L. Easun; David C. Grills; David A. McGovern; Jonathan McMaster; Jonathan Pitchford; Jayden A. Smith; Xue Zhong Sun; John M. Kelly; Michael W. George

doi:10.1039/c1pp05050h

Excited state dependent electron transfer of a rhenium-dipyridophenazine complex intercalated between the base pairs of DNA: A time-resolved UV-visible and IR absorption investigation into the photophysics of fac-[Re(CO) ₃(F₂dppz)(py)]⁺ bound to either [poly(dA-dT)]₂ or [poly(dG-dC)]₂

Qian Cao, Caitriona M. Creely, E. Stephen Davies, Joanne Dyer, Timothy L. Easun, David C. Grills, David A. McGovern, Jonathan McMaster, Jonathan Pitchford, Jayden A. Smith, Xue Zhong Sun, John M. Kelly, Michael W. George

Research output: Journal Publication › Article › peer-review

31 Citations (Scopus)

Abstract

The transient species formed following excitation of fac-[Re(CO) ₃(F₂dppz)(py)]⁺ (F₂dppz = 11,12-difluorodipyrido[3,2-a:2′,3′-c]phenazine) bound to double-stranded polynucleotides [poly(dA-dT)]₂ or [poly(dG-dC)] ₂ have been studied by transient visible and infra-red spectroscopy in both the picosecond and nanosecond time domains. The latter technique has been used to monitor both the metal complex and the DNA by monitoring the regions 1900-2100 and 1500-1750 cm^-1 respectively. These data provide direct evidence for electron transfer from guanine to the excited state of the metal complex, which proceeds both on a sub-picosecond time scale and with a lifetime of 35 ps, possibly due to the involvement of two excited states. No electron transfer is found for the [poly(dA-dT)]₂ complex, although characteristic changes are seen in the DNA-region TRIR consistent with changes in the binding of the bases in the intercalation site upon excitation of the dppz-complex.

Original language	English
Pages (from-to)	1355-1364
Number of pages	10
Journal	Photochemical and Photobiological Sciences
Volume	10
Issue number	8
DOIs	https://doi.org/10.1039/c1pp05050h
Publication status	Published - Aug 2011
Externally published	Yes

ASJC Scopus subject areas

Physical and Theoretical Chemistry

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Cao, Q., Creely, C. M., Davies, E. S., Dyer, J., Easun, T. L., Grills, D. C., McGovern, D. A., McMaster, J., Pitchford, J., Smith, J. A., Sun, X. Z., Kelly, J. M., & George, M. W. (2011). Excited state dependent electron transfer of a rhenium-dipyridophenazine complex intercalated between the base pairs of DNA: A time-resolved UV-visible and IR absorption investigation into the photophysics of fac-[Re(CO) ₃(F₂dppz)(py)]⁺ bound to either [poly(dA-dT)]₂ or [poly(dG-dC)]₂. Photochemical and Photobiological Sciences, 10(8), 1355-1364. https://doi.org/10.1039/c1pp05050h

Cao, Qian ; Creely, Caitriona M. ; Davies, E. Stephen et al. / Excited state dependent electron transfer of a rhenium-dipyridophenazine complex intercalated between the base pairs of DNA : A time-resolved UV-visible and IR absorption investigation into the photophysics of fac-[Re(CO) ₃(F₂dppz)(py)]⁺ bound to either [poly(dA-dT)]₂ or [poly(dG-dC)]₂. In: Photochemical and Photobiological Sciences. 2011 ; Vol. 10, No. 8. pp. 1355-1364.

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title = "Excited state dependent electron transfer of a rhenium-dipyridophenazine complex intercalated between the base pairs of DNA: A time-resolved UV-visible and IR absorption investigation into the photophysics of fac-[Re(CO) 3(F2dppz)(py)]+ bound to either [poly(dA-dT)]2 or [poly(dG-dC)]2",

abstract = "The transient species formed following excitation of fac-[Re(CO) 3(F2dppz)(py)]+ (F2dppz = 11,12-difluorodipyrido[3,2-a:2′,3′-c]phenazine) bound to double-stranded polynucleotides [poly(dA-dT)]2 or [poly(dG-dC)] 2 have been studied by transient visible and infra-red spectroscopy in both the picosecond and nanosecond time domains. The latter technique has been used to monitor both the metal complex and the DNA by monitoring the regions 1900-2100 and 1500-1750 cm-1 respectively. These data provide direct evidence for electron transfer from guanine to the excited state of the metal complex, which proceeds both on a sub-picosecond time scale and with a lifetime of 35 ps, possibly due to the involvement of two excited states. No electron transfer is found for the [poly(dA-dT)]2 complex, although characteristic changes are seen in the DNA-region TRIR consistent with changes in the binding of the bases in the intercalation site upon excitation of the dppz-complex.",

author = "Qian Cao and Creely, {Caitriona M.} and Davies, {E. Stephen} and Joanne Dyer and Easun, {Timothy L.} and Grills, {David C.} and McGovern, {David A.} and Jonathan McMaster and Jonathan Pitchford and Smith, {Jayden A.} and Sun, {Xue Zhong} and Kelly, {John M.} and George, {Michael W.}",

year = "2011",

month = aug,

doi = "10.1039/c1pp05050h",

language = "English",

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pages = "1355--1364",

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Cao, Q, Creely, CM, Davies, ES, Dyer, J, Easun, TL, Grills, DC, McGovern, DA, McMaster, J, Pitchford, J, Smith, JA, Sun, XZ, Kelly, JM & George, MW 2011, 'Excited state dependent electron transfer of a rhenium-dipyridophenazine complex intercalated between the base pairs of DNA: A time-resolved UV-visible and IR absorption investigation into the photophysics of fac-[Re(CO) ₃(F₂dppz)(py)]⁺ bound to either [poly(dA-dT)]₂ or [poly(dG-dC)]₂', Photochemical and Photobiological Sciences, vol. 10, no. 8, pp. 1355-1364. https://doi.org/10.1039/c1pp05050h

Excited state dependent electron transfer of a rhenium-dipyridophenazine complex intercalated between the base pairs of DNA: A time-resolved UV-visible and IR absorption investigation into the photophysics of fac-[Re(CO) ₃(F₂dppz)(py)]⁺ bound to either [poly(dA-dT)]₂ or [poly(dG-dC)]₂. / Cao, Qian; Creely, Caitriona M.; Davies, E. Stephen et al.
In: Photochemical and Photobiological Sciences, Vol. 10, No. 8, 08.2011, p. 1355-1364.

Research output: Journal Publication › Article › peer-review

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Cao Q, Creely CM, Davies ES, Dyer J, Easun TL, Grills DC et al. Excited state dependent electron transfer of a rhenium-dipyridophenazine complex intercalated between the base pairs of DNA: A time-resolved UV-visible and IR absorption investigation into the photophysics of fac-[Re(CO) ₃(F₂dppz)(py)]⁺ bound to either [poly(dA-dT)]₂ or [poly(dG-dC)]₂. Photochemical and Photobiological Sciences. 2011 Aug;10(8):1355-1364. doi: 10.1039/c1pp05050h