Excellent antimicrobial performances of Cu(II) metal organic framework@Fe3O4 fused cubic particles

Riffat Ameen, Abdul Rauf, Ayesha Mohyuddin, Mohsin Javed, Shahid Iqbal, Sohail Nadeem, Komal Aroosh, Aziz ur Rehman Aziz, Ahmad Alhujaily, Randa A. Althobiti, Eman Alzahrani, Abd El Aziem Farouk, Foziah F. Al-Fawzan, Eslam B. Elkaeed

Research output: Journal PublicationArticlepeer-review

6 Citations (Scopus)

Abstract

Metal-organic frameworks have been used as antibacterial agents because of their effective antibacterial properties. In this research, nanocomposites of copper (II)- benzene-1,4-dicarboxylic acid metal–organic framework with iron oxide [Cu-MOF@Fe3O4] were prepared via a simple hydrothermal route. X-ray analysis reveals the crystallinity of the structure while FTIR analysis confirms the existence of Cu-based MOFs functional group. Cu-MOF@Fe3O4 scans using Scanning Electron Microscopy (SEM) reveal irregular clusters of cubic particles fused with Fe3O4 nanoparticles. Energy Dispersive X-ray (EDX) spectrum of Cu-MOF@Fe3O4 provides the evidence of elemental composition by showing the peaks of iron, oxygen, copper and carbon. Using the minimum inhibitory concentration (MIC) and zone of inhibition assays, the antimicrobial activity of the Cu-MOF and Cu-MOF@Fe3O4 against E. coli and B. subtilis were evaluated. The antibacterial results have shown that the Cu-MOF@Fe3O4 has higher antibacterial performance against E. coli as compared with B. subtilis as compared to Cu-MOF, Fe3O4 and ligands only. On the other hand, the Cu-MOF@Fe3O4 composites exhibit excellent antifungal potential when compared to the ligand, commercial nanoparticles, Cu(NO3)2·3H2O, iron oxide, Cu-MOF. The exploration of antibacterial mechanism revealed that the Cu-MOF@Fe3O4 composite favors slow release of metal ions and prolonged biocidal effect.

Original languageEnglish
Article number101762
JournalJournal of Saudi Chemical Society
Volume27
Issue number6
DOIs
Publication statusPublished - Nov 2023

Keywords

  • Antibacterial activity
  • Antibacterial mechanism
  • Cu-MOF@FeO nanocomposite
  • Hydrothermal route

ASJC Scopus subject areas

  • General Chemistry

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