Evaluating cellular uptake of gold nanoparticles in HL-7702 and HepG2 cells for plasmonic photothermal therapy

Peng Wang, Qiang Wu, Fuyan Wang, Yaping Zhang, Liying Tong, Tao Jiang, Chenjie Gu, Shuiping Huang, Hongxi Wang, Shizhong Bu, Jun Zhou

Research output: Journal PublicationArticlepeer-review

10 Citations (Scopus)

Abstract

A novel method is proposed for quantifying the Raman intensity as a function of gold mass in a single cell based on the Raman mapping and inductively coupled plasma-mass spectrometry techniques. A high-efficiency plasmonic photothermal therapy has also been achieved by adjusting the laser wavelength, laser power and exposure time, resulting in most of the HL-7702 cells surviving, whereas most of the HepG2 cells get damaged.

Original languageEnglish
Pages (from-to)2245-2259
Number of pages15
JournalNanomedicine
Volume13
Issue number18
DOIs
Publication statusPublished - 1 Sep 2018

Keywords

  • ICP-MS
  • Raman mapping
  • cellular uptake
  • cytotoxicity
  • gold nanoparticles
  • human hepatic immortalized cell lines (HL-7702)
  • human hepatocellular carcinoma cell lines (HepG2)
  • plasmonic photothermal therapy
  • surface enhanced Raman scattering (SERS)

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Materials Science (all)

Fingerprint

Dive into the research topics of 'Evaluating cellular uptake of gold nanoparticles in HL-7702 and HepG2 cells for plasmonic photothermal therapy'. Together they form a unique fingerprint.

Cite this