Epoxy resin-based ultrafine dry powder coatings for implants

Nicholas Y. Hou, Jesse Zhu, Hui Zhang, Hiran Perinpanayagam

Research output: Journal PublicationArticlepeer-review

9 Citations (Scopus)

Abstract

Ultrafine dry powder coating technology creates biocompatible polymeric coatings for implants. Nanoparticles (nTiO2) modify flow to prevent agglomeration and create homogenous coatings. Since polyester-based coatings require the potentially harmful 1,3,5-triglycidyl isocyanurate (TGIC) curing agent, this study's objective was to develop alternative TGIC-free formulations. Epoxy and epoxy/polyester (1:1) hybrid mixtures were enriched with CaO (5% w/w) and nTiO2 (0.5% w/w), as functional additives and flow modifiers, respectively. Epoxy-TiO2 and Hybrid-TiO2 mixtures were prepared with micron-sized TiO2 (25% w/w) to enhance biocompatibility. Polymer chips and additives were combined in a high-shear mixer and passed through a sieve (35 µm) to yield ultrafine particles that were sprayed (20 kV) onto metal sheets and cured (200 °C). Particle size analyses showed that all formulations were ultrafine (D 0.5 < 35 µm), and epoxy/polyester/TiO2 mixtures were the smallest (D 0.5 = 16.34 µm). Angles of repose, avalanche and resting indicated reduced flowability when epoxy was enriched with TiO2 and/or polyester, although all formulae were highly flowable. Elemental mapping of coatings showed a predominance of carbon (C) and oxygen (O) from resin polymer, and elevated titanium (Ti) in the TiO2 enriched surfaces. However, calcium (Ca) clusters were higher on the epoxy/polyester Hybrid coatings. Optical microscopy showed human mesenchymal cells (ATCC CRL-1486) attached and spread out, and Alizarin Red staining showed mineral deposits in 2–4 week cultures, particularly on epoxy/polyester/TiO2 Hybrid surfaces. These epoxy resin-based formulations were effective TGIC-free substitutes for ultrafine dry powder coatings on implants.

Original languageEnglish
Article numberAPP43960
JournalJournal of Applied Polymer Science
Volume133
Issue number37
DOIs
Publication statusPublished - 5 Oct 2016
Externally publishedYes

Keywords

  • biocompatibility
  • biomaterials
  • coatings
  • nanoparticles
  • nanowires and nanocrystals
  • resins

ASJC Scopus subject areas

  • Chemistry (all)
  • Surfaces, Coatings and Films
  • Polymers and Plastics
  • Materials Chemistry

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