TY - GEN
T1 - Electrospun PCL/TPU/CA based nanocomposite for potential use as implants in tympanic membrane (TM) repair
AU - Nuge, Tamrin
AU - Singh, Jaslin Kaur A.P.Ranjit
AU - Al-Dhahebi, Adel M.Mohammed
AU - Yusuf, Nur'Aini Raman
AU - Zaki, Yuzaida Hair
AU - Saheed, M. Shuaib M.
N1 - Publisher Copyright:
© 2023 IEEE.
PY - 2023
Y1 - 2023
N2 - Electrospun nanocomposites have received great deals of interest for soft tissue engineered implants including tympanic membrane TM repaired. In this work, an innovative PCL/TPU/CA nanocomposite were fabricated via the electrospinning technology. The physico-mechanical properties of the nanocomposites exhibit favorable properties for tissue regeneration. This work has shown that the properties of the nanocomposite can be tuning to desirable properties that mimics the human TM by adjusting the cellulose acetate (CA) concentration during the electrospinning process. The elastic modulus of the nanocomposite has increased to 130 MPa after addition 30 % of CA, which meet the minimum requirement for human TM at 45 MPa. Highly porous and hydrophilic in nature of the nanocomposites make them a very good candidate to be considered for chronic tympanic membrane repair as these surface properties are anticipated to facilitate cell migration and proliferation in tissue regeneration.
AB - Electrospun nanocomposites have received great deals of interest for soft tissue engineered implants including tympanic membrane TM repaired. In this work, an innovative PCL/TPU/CA nanocomposite were fabricated via the electrospinning technology. The physico-mechanical properties of the nanocomposites exhibit favorable properties for tissue regeneration. This work has shown that the properties of the nanocomposite can be tuning to desirable properties that mimics the human TM by adjusting the cellulose acetate (CA) concentration during the electrospinning process. The elastic modulus of the nanocomposite has increased to 130 MPa after addition 30 % of CA, which meet the minimum requirement for human TM at 45 MPa. Highly porous and hydrophilic in nature of the nanocomposites make them a very good candidate to be considered for chronic tympanic membrane repair as these surface properties are anticipated to facilitate cell migration and proliferation in tissue regeneration.
KW - electrospinning
KW - microstructure
KW - scaffolds
UR - http://www.scopus.com/inward/record.url?scp=85182732230&partnerID=8YFLogxK
U2 - 10.1109/SENNANO57767.2023.10352530
DO - 10.1109/SENNANO57767.2023.10352530
M3 - Conference contribution
AN - SCOPUS:85182732230
T3 - 2023 IEEE International Conference on Sensors and Nanotechnology, SENNANO 2023
SP - 241
EP - 244
BT - 2023 IEEE International Conference on Sensors and Nanotechnology, SENNANO 2023
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2023 IEEE International Conference on Sensors and Nanotechnology, SENNANO 2023
Y2 - 26 September 2023 through 27 September 2023
ER -