Electrospun PCL/TPU/CA based nanocomposite for potential use as implants in tympanic membrane (TM) repair

Tamrin Nuge, Jaslin Kaur A.P.Ranjit Singh, Adel M.Mohammed Al-Dhahebi, Nur'Aini Raman Yusuf, Yuzaida Hair Zaki, M. Shuaib M. Saheed

Research output: Chapter in Book/Conference proceedingConference contributionpeer-review

Abstract

Electrospun nanocomposites have received great deals of interest for soft tissue engineered implants including tympanic membrane TM repaired. In this work, an innovative PCL/TPU/CA nanocomposite were fabricated via the electrospinning technology. The physico-mechanical properties of the nanocomposites exhibit favorable properties for tissue regeneration. This work has shown that the properties of the nanocomposite can be tuning to desirable properties that mimics the human TM by adjusting the cellulose acetate (CA) concentration during the electrospinning process. The elastic modulus of the nanocomposite has increased to 130 MPa after addition 30 % of CA, which meet the minimum requirement for human TM at 45 MPa. Highly porous and hydrophilic in nature of the nanocomposites make them a very good candidate to be considered for chronic tympanic membrane repair as these surface properties are anticipated to facilitate cell migration and proliferation in tissue regeneration.

Original languageEnglish
Title of host publication2023 IEEE International Conference on Sensors and Nanotechnology, SENNANO 2023
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages241-244
Number of pages4
ISBN (Electronic)9798350333312
DOIs
Publication statusPublished - 2023
Event2023 IEEE International Conference on Sensors and Nanotechnology, SENNANO 2023 - Putrajaya, Malaysia
Duration: 26 Sept 202327 Sept 2023

Publication series

Name2023 IEEE International Conference on Sensors and Nanotechnology, SENNANO 2023

Conference

Conference2023 IEEE International Conference on Sensors and Nanotechnology, SENNANO 2023
Country/TerritoryMalaysia
CityPutrajaya
Period26/09/2327/09/23

Keywords

  • electrospinning
  • microstructure
  • scaffolds

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Materials Science (miscellaneous)
  • Electronic, Optical and Magnetic Materials
  • Polymers and Plastics
  • Instrumentation

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